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Scientists may found a way to delay aging

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Scientists may found a way to delay aging

Getting old is inevitable, but scientists at the University of California San Diego (UCSD) may be one step closer to being able to delay the aging process.

A team of scientists studied aging in yeast — chosen because its cells are easily manipulated — to try and understand if different cells age at the same rate, and for the same reason.

What they found was intriguing. Even cells made of the same genetic materials and within the same environment aged in “strikingly distinct ways,” according to the scientists, who published their findings in the journal Science.

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About half of the yeast cells aged because of a gradual decline in the nucleolus, a round body located in the nucleus of a cell, the scientists learned, by using techniques including microfluidics and computer modeling.

However, the other half aged because of a dysfunction of mitochondria, which produce a cell’s energy.

Scientists said that the cells go down one of two paths — nuclear or mitochondrial — early in life, and they continue with the aging route until they ultimately decline and die.

Researchers performed further tests to understand how the cells behaved.

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“To understand how cells make these decisions, we identified the molecular processes underlying each aging route and the connections among them, revealing a molecular circuit that controls cell aging, analogous to electric circuits that control home appliances,” said Nan Hao, senior author of the study and an associate professor in UCSD’s division of biological sciences’ molecular biology section.

After modeling the “aging landscape,” the team of researchers found they could manipulate — and optimize — the process of aging, using computer simulations to reprogram the master circuit and modify its DNA.

They were then able to create a “novel aging route,” with a dramatically extended lifespan. This, researchers believe, could ultimately lead to the possibility of delaying human aging.

“This is an aging path that never existed, but because we understand how it is regulated, we can basically design or regulate a new aging path,” Hao told .

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“Our study raises the possibility of rationally designing gene or chemical-based therapies to reprogram how human cells age, with a goal of effectively delaying human aging and extending human healthspan,” Hao said in a statement.

Scientists said that they plan to test their model in complex cells, organisms, and eventually, humans, as well as testing how combinations of therapeutics and drugs could lead to further longevity.

“Aging is a fundamental biological question. We know very little about the aging process,”

When it comes to medical relevance, , “aging is related to many diseases so if we can help slow aging or promote longevity, it will be beneficial for society.”

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Source : CNN

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Amitabh Bachchan Fan Faints After Hours of Torturous Waiting

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Amitabh Bachchan: Shocking Fan Incident Outside Jalsa

Amitabh Bachchan Fan Faints After Hours of Torturous Waiting

The weekly Sunday rite outside the renowned gates of Jalsa is nothing short of profoundly holy. For decades, thousands of deeply moved admirers have gathered like clockwork, hoping for a single glimpse of the iconic megastar.

Yesterday evening, that fierce commitment took a scary and sad turn. A middle-aged guy, who had been standing patiently in the scorching midday sun for more than four hours, collapsed unexpectedly.

He collapsed totally into profound sleep, landing directly on the harsh, unforgiving asphalt road. The happy, chanting crowd fell silent in an instant as reality hit in.

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A Heartbreaking Moment of Desperation

According to eyewitnesses, this enthusiast travelled across various states for a two-minute glimpse of his idol. His quivering hands clutched a framed vintage photograph of the superstar.

As the searing midday heat reached its zenith, acute dehydration and utter physical fatigue overtook his body. His feeble knees bowed under the crushing weight of his never-ending, frantic wait.

He fell face first to the ground before anyone could react or grab him. The enormous crowd’s collective, frightened gasp boomed over Juhu’s normally peaceful suburban streets.


Sudden Chaos Outside Jalsa’s Gates

Within seconds, total fear spread among the observers. Fellow supporters quickly dropped their homemade banners and posters, coming to the fallen man’s rescue. Someone desperately sprayed cold water upon his pale, sweating face.

The large security crew stationed outside Amitabh Bachchan’s home acted quickly. They were able to remove the rising, panicked crowd, allowing the choking sufferer to breathe easier.

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An emergency ambulance was dispatched immediately, while local volunteers attempted to revive him. In a few startling moments, the atmosphere went from exhilarating exhilaration to total horror.


The Relentless Sunday Evening Madness

Every Sunday evening, the veteran actor gracefully goes onto a high podium at his grand gates. It is a renowned custom that has completely defined Bollywood fan culture over generations.

Passionate admirers will miss meals, risk heavy monsoons, and suffer harsh summer heat waves only to see him wave. It is a profound, emotional bond that defies all reasonable logic.

For this heartbreakingly loyal admirer, the powerful emotional rush combined with severe physical tiredness proved to be a highly perilous, almost lethal combination on the boiling, sweltering concrete.

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Security Personnel Scramble to Prevent Tragedy

Local police officers responded promptly to the chaotic scene, attempting to manage the emotionally charged throng. Medical staff administered quick, vital first aid on the scene, examining his critically weak and decreasing pulse.

The comatose man was gingerly put onto a canvas stretcher, still clutching his prized, sweat-soaked image of the actor. He was sent to a local hospital for emergency treatment.

On-duty medics eventually confirmed that he had severe heatstroke and acute, life-threatening dehydration. Fortunately, his medical condition improved after he received repeated IV infusions and intensive, appropriate care.


A Stark Warning for Star-Worshippers

This terrible, tragic episode has generated a heated, much-needed debate about the extreme limits of celebrity worship in India. Blind passion should never result in the death of an innocent person.

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Jalsa is an undisputed historical monument to love, but yesterday it served as a grim, sobering lesson. Extreme physical endurance for a brief moment can easily result in a catastrophic medical tragedy.

As thousands of passionate individuals continue to flow to Mumbai every day, the fine line between beautiful appreciation and life-threatening devotion becomes increasingly, dangerously blurred for these fragile worshippers.


Terrifying Boundaries of Human Obsession

The burning passion that motivates these ordinary folks to risk their own health is both wonderful and scary. It emphasises the megastar’s immense, godlike influence over millions of hearts.

While the legendary actor continues to express love to his devoted fans, this dangerous occurrence demonstrates that safety should always come first. No fan should have to bleed or faint on the street in order to catch a passing shadow.

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