Malaria vaccines may improve with new information on naturally acquired immunity

Published

5 years ago

November 16, 2021

India

Malaria vaccines may improve with new information on naturally acquired immunity

Scientists all over the world are trying to understand malaria parasite infections to combat them. Researchers at the University of Copenhagen have taken an important step because they discovered an important difference between naturally acquired immunity and immunity after vaccination. The results of the study were published in the journal Nature Communications.

“The antibodies produced by the body when infected with malaria look different from the antibodies produced by the body when vaccinated. This may mean that when we are naturally infected, our immune system has a more effective response to malaria vaccine than when we are naturally infected,” Said Lars Hviid, a professor in the Department of Immunology and Microbiology.

The immune system can trigger various mechanisms to protect the body. The usual defenses against parasites, viruses and bacterial infections consist of so-called macrophages. “When we are attacked from the outside, the immune system produces antibodies that attach to foreign objects that need to be resisted. They are then recognized by small cells called macrophages, which are attracted by antibodies and eat bacteria or viruses. This is basically how immunity to most infectious diseases works,” Lars Hviid explained.

However, now, researchers have found that immunity to malaria seems to be different. Here, the body’s immune system uses some other types of cells to fight against malaria parasite infections. “We found that antibodies look different, depending on whether you have been vaccinated or infected. This means that the body activates some other defense mechanism because it uses what we call natural killer cells,” Lars Hviid said. Researchers generally believe that natural killer cells are one of the body’s best weapons against cancer cells.

However, it now appears that the defense against malaria and the immune system against cancer have common characteristics. “In layman’s terms, you can say that the immune system’s defenses against malaria are more targeted than other typical infections. Maybe we evolved in this way because it is a contagious and deadly disease-it’s hard to guess. ,” Lars Hevid said.

The researchers made this finding by comparing blood samples from Ghanaians infected with malaria with blood samples from people participating in a phase 1 clinical trial of an experimental malaria vaccine. He explained that the new knowledge can be used to develop new and improved malaria vaccines.

“Our research points to new strategies for developing better malaria vaccines in the future. Because, now, we know how the body uses natural killer cells to mobilize defenses, and we can use vaccines to imitate them,” he said.

News Source : Hindustan Times

Related Topics:Featured improve information malaria naturally

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Amitabh Bachchan: The Heartbreaking Anxiety of Bollywood’s Greatest Icon

Published

6 days ago

June 19, 2026

Digital Post

Amitabh Bachchan: Candid Self-Doubt Confession

Even after five decades of cinematic dominance, Amitabh Bachchan still faces the quiet terrors of the midnight hour. The man who epitomised alpha-masculinity for generations of moviegoers recently made an unexpected confession that shocked his millions of admirers. He continues to have restless nights, locked in a vicious circle of intense self-doubt and crushing work stress.

This revelation is a huge wake-up call for anyone who thinks of him as an invincible acting colossus. It demonstrates that the heavy weight of perfectionism never fully fades, no matter how much celebrity you achieve.

The Haunting Midnight Echoes of Perfectionism

Imagine being a living legend and lying awake at 3 a.m. wondering if your previous performance was a complete failure. Bachchan admitted that he always repeats his sequences in his memory, haunted by the terrible feeling that they “could have been done better.”

This tremendous emotional sensitivity reveals a side of the megastar that the public has rarely seen. Onscreen, we witness the towering demeanour, booming baritone voice, and perfect delivery. But, behind closed doors, he suffers from the same paralysing fear that ordinary people face on a daily basis in the workplace.

Why the Deepest Passion Breeds Internal Chaos

You might ask why a man who has won every major film award is so concerned about delivering a single sentence. True genius is rarely characterised by serenity of mind. For Bachchan, acting is more than a job; it is a sacred, consuming fire that demands flawless excellence every time.

When you care so deeply about your craft, every creative endeavour feels like a high-stakes bet on your entire legacy. This tremendous artistic drive is a two-edged blade that produces amazing art while completely destroying your mental serenity.

The Heavy Price of an Enduring Legacy

Living under the microscope of the public eye for fifty years has a catastrophic psychological impact. Every move Amitabh Bachchan makes is immediately analysed, criticised, or worshipped by countless millions of people.

That amount of tremendous expectation establishes a distinct, invisible prison of performance anxiety. The dreadful anxiety of disappointing his big audience keeps his thoughts racing long after the cameras stop rolling. It turns out that the view from the very top of the mountain is extremely lonely and filled with perpetual emotional danger.

Normalizing the Silent Struggle with Mental Health

Bachchan has done an incredible amount to raise worldwide mental health awareness by publicly exposing his personal struggles with work stress. He has effectively removed the heavy veil of shame that typically surrounds the topic of anxiety, particularly among older generations.

If the ultimate “Angry Young Man” of Indian cinema can freely acknowledge to feeling inadequate, then everyone else has the right to be human as well. It is a welcome reminder that being overburdened by your commitments does not imply weakness.

The Relentless Creative Hunger That Never Sleeps

Finally, this severe self-doubt is the secret fuel that drives Amitabh Bachchan to labour continuously at an age when most people have retired. It’s a curious paradox: his severe inner agony serves as the driving reason behind his legendary longevity.

He refuses to rest on his past accomplishments or rely on his immense celebrity to get by. Every sleepless night reveals a man with the raw, eager heart of a novice. He remains gloriously, devastatingly uneasy about his work, which is precisely what makes him an everlasting force in film.

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