India Hot Topics

Transcriptomics identifies possible COVID-19 therapies

Published

6 years ago

October 27, 2020

India

Transcriptomics identifies possible COVID-19 therapies

By the usage of a various set of transcriptomic SARS-CoV-2 signatures, US researchers placed to apply their formerly advanced drug repositioning pipeline to pinpoint capacity drug applicants for the remedy of coronavirus disease (COVID-19). The take a look at is presently to be had at the bioRxiv* preprint server.
While many efforts are presently underway to perceive capacity treatment options concentrated on numerous components of COVID-19, as a result of the extreme acute breathing syndrome coronavirus 2 (SARS-CoV-2), there may be nevertheless a loss of clinically tested procedures to be had in our armamentarium.
Drug repositioning is one of the procedures that has been appreciably explored in the course of this pandemic. More specifically, high-throughput screening pipelines had been placed forth as possible techniques to check drug applicants as they’re diagnosed quickly.
A comparable technique has been taken through a set of scientists led through Dr. Brian L. Le from the Department of Pediatrics and Bakar Computational Health Sciences Institute on the University of California San Francisco.
In this take a look at, the researchers implemented their current computational drug repositioning pipeline to SARS-CoV-2 differential gene expression signatures derived from publicly to be had RNA-sequencing (RNA-seq) records. The transcriptomic records has been generated from awesome forms of tissues, because of this that they may are expecting therapeutics for every signature after which integrate the results.
Moreover, validity turned into showed through displaying sixteen in their drug hits’ inhibitory outcomes, that may notably opposite more than one SARS-CoV-2 profiles in stay antiviral assays. Two forms of mobileular traces had been used: Calu-3 (human lung mobileular line) and kidney 293T cells overexpressing ACE2 (293T-ACE2 cells).
Finally, the usage of a rank-primarily based totally pattern-matching method primarily based totally at the non-parametric and distribution-loose Kolmogorov-Smirnov statistic, the signatures had been queried in opposition to drug profiles from Connectivity Map (Cmap) – a aid that makes use of transcriptional expression records in probing relationships among diseases, mobileular physiology, and therapeutics.
Twenty-5 not unusualplace drug hits had been shared through at the least of the signatures (p = 0.0334), with 4 consensus drug hits (bacampicillin, clofazimine, haloperidol, valproic acid) throughout all 3 signatures (p = 0.0599) (A). Characterized not unusualplace hits through inspecting interactions with proteins in humans. Known drug objectives from DrugBank32 and expected extra objectives the usage of the similarity ensemble technique (SEA)33. Visualized the recognised interactions from DrugBank in a network
Overall, through utilising a various set of transcriptomic SARS-CoV-2 signatures throughout human mobileular line assays, the researchers diagnosed 25 capacity healing applicants from 102 specific drug hits. Further validation experiments found out SARS-CoV-2 antiviral interest for eleven of sixteen drug hits.
This take a look at confirms the strength of those predictive strategies and efficiently diagnosed exceptional clinically-authorised tablets with repurposing capacity for the remedy of COVID-19 – lots of which may be administered orally.
Hence, the variety of observed signatures and the overlap of highlighted tablets accentuates the software of the contemporary pipeline for unveiling tablets which have healing outcomes for a big range of SARS-CoV-2 contamination outcomes.
Still, numerous boundaries of this kind of technique have to be recognized. First and foremost, records generated from mobileular traces won’t efficiently constitute the organic modifications and manifold responses in human contamination. Moreover, the drug profiles from Cmap had been generated from mobileular line records.
Encouraged through those preliminary results, destiny studies endeavors on the subject have to acquire samples from a bigger pool of sufferers to achieve a far better gene expression signature and higher tell any remedy predictions.

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Cricket

Anushka Sharma Cheers as Smriti Mandhana’s RCB Makes History with Second WPL Title!

Published

4 months ago

February 6, 2026

Digital Post

Anushka Sharma hails RCB: Powerful Historic WPL Triumph

The air was thick with expectancy, the stadium buzzed with electricity, and everyone’s attention was focused on the emerging drama. The Women’s Premier League (WPL) final, which pitted Royal Challengers Bangalore (RCB) against Delhi Capitals (DC), promised to be a spectacular spectacle. We had no idea it would provide so much more – a nail-biting match culminating in a historic victory that sent shockwaves of joy around the cricketing globe, and no one was more excited than Bollywood diva Anushka Sharma. Her exuberant exclamation of “History repeated!” wonderfully captured the enthusiasm surrounding RCB’s stunning win, their second consecutive WPL title.

A Season of Resilience and Redemption

The Journey to the Final

RCB’s path through the WPL season was one of resilience, strategic brilliance, and unwavering commitment. Smriti Mandhana’s dynamic leadership led to continual growth, with the team learning from each setback and emerging stronger. Their route to the final was not without challenges, but each one strengthened their resolve, transforming them into a strong force eager to triumph.

Mandhana’s Masterclass in Leadership

Smriti Mandhana, known for her graceful batting, shone as a captain throughout the season. Her cool demeanour under pressure, clever tactical selections, and ability to motivate her teammates all contributed to RCB’s win. She led from the front, both with the bat and as captain, exemplifying the spirit of true leadership.

The Grand Finale: A Battle for Supremacy

DC’s Strong Start

The final against the Delhi Capitals was a match worthy of the occasion. DC, a powerhouse squad, started strong, scoring a tough total that tested RCB’s batting lineup. The early overs were tense, with both sides trading blows as they battled for dominance in the high-stakes match.

RCB’s Clinical Chase

However, the RCB chase was nothing short of clinical. The batsmen showed steel nerves, forming key partnerships and patiently chipping away at the objective. Each run was greeted with enthusiasm, and each boundary elicited tremendous ovation, as the momentum changed in RCB’s favour.

Anushka Sharma’s Elation: A True Fan’s Delight

Beyond The Boundary Ropes

Anushka Sharma, a loud and avid supporter of RCB – and, in fact, of all things cricket, given her husband Virat Kohli’s involvement with the men’s squad – has always been interested in the team’s success. Her presence, though virtual this time, was palpable. Her social media was buzzing with enthusiasm as she tracked every ball, wicket, and run.

“History Repeated!” – A Resounding Declaration

Upon RCB’s momentous victory, Anushka’s joy knew no bounds. Her initial reaction, “History repeated!”, was more than just a congratulatory statement; it was a genuine recognition of the team’s amazing feat. It struck a chord with fans, bringing back memories of RCB’s previous WPL victory and emphasising the squad’s consistent excellence under Smriti Mandhana. This victory was more than simply a single win; it was a declaration of purpose, confirming their place as the dominant force in women’s cricket.

The Impact of Victory

Inspiring a New Generation

RCB’s straight WPL wins are more than simply trophies; they serve as a source of motivation for a generation of ambitious female cricket players. These achievements highlight the incredible skill, devotion, and professionalism of women’s cricket, inspiring young girls to pursue their aspirations in the sport. The WPL’s visibility and success are critical in building a strong ecosystem for women’s cricket around the world.

Solidifying RCB’s Legacy

This second WPL triumph cements RCB’s legacy in the expanding world of women’s franchise cricket. It demonstrates their dedication to excellence, strategic team development, and developing top people. The team has not only won silverware, but it has also won hearts, resulting in a devoted and ever-growing fan base.

A Celebration of Teamwork and Tenacity

Every Player’s Contribution

The success was due to the combined efforts of all RCB players. From crucial bowling breakthroughs to critical runs scored by batters and great fielding exploits, each individual contribution is woven together to create a winning tapestry. It emphasised the value of teamwork, with each player playing an important role in achieving a common objective.

The Power of WPL

The WPL continues to grow in stature and popularity, giving an important platform for female cricketers to demonstrate their abilities on a worldwide scale. Matches such as the final between RCB and DC help to captivate fans and demonstrate the league’s tremendous competitiveness. The continued success of teams such as RCB only adds to the league’s allure and long-term viability.

Looking Ahead: A Bright Future

Maintaining Momentum

As RCB basks in the joy of winning back-to-back WPL titles, the issue now is to maintain that momentum. The cricket world will be looking to see how they evolve, innovate, and defend their championship status in the coming seasons. The benchmark has been established, and expectations are higher than ever.

The Expanding Reach of Women’s Cricket

The WPL’s success, fuelled by compelling finals and celebrity endorsements such as Anushka Sharma’s, demonstrates the growing reach and attraction of women’s cricket. It demonstrates the quality, passion, and rising fans that this format continues to attract, implying an even brighter future for the sport.

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