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Ailments in covid-19 trials raise questions about vaccine method

Published

6 years ago

October 18, 2020

India

Ailments in covid-19 trials raise questions about vaccine method

Two Covid-19 vaccines stalled by potential side effects have one key feature in common: Both are based on adenoviruses, cold germs that researchers have used in experimental therapies for decades with varying results.
Johnson & Johnson said late Monday it would pause its trial to investigate an illness, which it didn’t specify, in a study participant. Meanwhile, AstraZeneca Plc’s U.S. trial of the vaccine it’s developing with the University of Oxford has been halted by regulators for more than a month after neurological symptoms arose in two volunteers.
With AstraZeneca in a pit stop, vaccines from Moderna Inc. and the Pfizer Inc.-BioNTech SE partnership have taken the lead in the race to be first out with a shot. Meanwhile, the two paused trials are reviving questions about adenoviral vectors, which have been used in laboratory, animal and human experiments for years. In some cases, the experiments have succeeded, but not always.
And this year, with Covid-19 vaccines entering strongly into the politics of the hour, transparency and trust are key to fighting a virus that’s hit more than 39 million people globally and hamstrung economies. If concerns about side effects in experimental vaccines in trials using adenoviruses are validated, it could boost skepticism in the general public and raise questions for other drugmakers.
“While it could be a coincidence,” said Sam Fazeli, a Bloomberg Intelligence analyst, in a research note, “there’s still the possibility that adenoviral vector vaccines run a higher risk of rare side effects – such as autoimmune attacks like transverse myelitis – than those of Pfizer-BioNTech, Moderna or Novavax.”
Pauses to investigate side effects aren’t unusual in vaccine trials, which require a high safety bar because they’re taken by healthy people. Oxford has said there’s insufficient evidence to connect the participants’ illnesses to their vaccine. Its human tests in the U.K., South Africa and Brazil resumed weeks ago.
Adenoviral vectors are well studied, versatile, and shown to be well tolerated, making them good candidates for Covid vaccines, AstraZeneca said in an email. Reactions to the Astra/Oxford vaccine in early studies were comparable to those seen in previous trials of other vaccines using adenoviruses, the company said. Oxford researchers declined to comment.
If adenoviruses are associated with the side effects that have appeared in Covid vaccines, it may set back development of numerous projects, as it did with HIV and gene therapy. There are more than a dozen Covid vaccines in development based on adenoviruses, according to the World Health Organization.
Should investigators in the current trials determine the cause of the episodes is related to the vaccines, they would look for potential links to the adenovirus approach as well as to the spike protein the vaccine is designed to make to prepare the immune system for a real infection, according to Washington University’s Kinch.
At this point, he said, there’s not enough information to know. “Is this just random chance?” Kinch said. “First and foremost, there’s bad luck. If it turns out there’s a correlation and a causation, then the conversation very quickly turns.”

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Cricket

Anushka Sharma Cheers as Smriti Mandhana’s RCB Makes History with Second WPL Title!

Published

4 months ago

February 6, 2026

Digital Post

Anushka Sharma hails RCB: Powerful Historic WPL Triumph

The air was thick with expectancy, the stadium buzzed with electricity, and everyone’s attention was focused on the emerging drama. The Women’s Premier League (WPL) final, which pitted Royal Challengers Bangalore (RCB) against Delhi Capitals (DC), promised to be a spectacular spectacle. We had no idea it would provide so much more – a nail-biting match culminating in a historic victory that sent shockwaves of joy around the cricketing globe, and no one was more excited than Bollywood diva Anushka Sharma. Her exuberant exclamation of “History repeated!” wonderfully captured the enthusiasm surrounding RCB’s stunning win, their second consecutive WPL title.

A Season of Resilience and Redemption

The Journey to the Final

RCB’s path through the WPL season was one of resilience, strategic brilliance, and unwavering commitment. Smriti Mandhana’s dynamic leadership led to continual growth, with the team learning from each setback and emerging stronger. Their route to the final was not without challenges, but each one strengthened their resolve, transforming them into a strong force eager to triumph.

Mandhana’s Masterclass in Leadership

Smriti Mandhana, known for her graceful batting, shone as a captain throughout the season. Her cool demeanour under pressure, clever tactical selections, and ability to motivate her teammates all contributed to RCB’s win. She led from the front, both with the bat and as captain, exemplifying the spirit of true leadership.

The Grand Finale: A Battle for Supremacy

DC’s Strong Start

The final against the Delhi Capitals was a match worthy of the occasion. DC, a powerhouse squad, started strong, scoring a tough total that tested RCB’s batting lineup. The early overs were tense, with both sides trading blows as they battled for dominance in the high-stakes match.

RCB’s Clinical Chase

However, the RCB chase was nothing short of clinical. The batsmen showed steel nerves, forming key partnerships and patiently chipping away at the objective. Each run was greeted with enthusiasm, and each boundary elicited tremendous ovation, as the momentum changed in RCB’s favour.

Anushka Sharma’s Elation: A True Fan’s Delight

Beyond The Boundary Ropes

Anushka Sharma, a loud and avid supporter of RCB – and, in fact, of all things cricket, given her husband Virat Kohli’s involvement with the men’s squad – has always been interested in the team’s success. Her presence, though virtual this time, was palpable. Her social media was buzzing with enthusiasm as she tracked every ball, wicket, and run.

“History Repeated!” – A Resounding Declaration

Upon RCB’s momentous victory, Anushka’s joy knew no bounds. Her initial reaction, “History repeated!”, was more than just a congratulatory statement; it was a genuine recognition of the team’s amazing feat. It struck a chord with fans, bringing back memories of RCB’s previous WPL victory and emphasising the squad’s consistent excellence under Smriti Mandhana. This victory was more than simply a single win; it was a declaration of purpose, confirming their place as the dominant force in women’s cricket.

The Impact of Victory

Inspiring a New Generation

RCB’s straight WPL wins are more than simply trophies; they serve as a source of motivation for a generation of ambitious female cricket players. These achievements highlight the incredible skill, devotion, and professionalism of women’s cricket, inspiring young girls to pursue their aspirations in the sport. The WPL’s visibility and success are critical in building a strong ecosystem for women’s cricket around the world.

Solidifying RCB’s Legacy

This second WPL triumph cements RCB’s legacy in the expanding world of women’s franchise cricket. It demonstrates their dedication to excellence, strategic team development, and developing top people. The team has not only won silverware, but it has also won hearts, resulting in a devoted and ever-growing fan base.

A Celebration of Teamwork and Tenacity

Every Player’s Contribution

The success was due to the combined efforts of all RCB players. From crucial bowling breakthroughs to critical runs scored by batters and great fielding exploits, each individual contribution is woven together to create a winning tapestry. It emphasised the value of teamwork, with each player playing an important role in achieving a common objective.

The Power of WPL

The WPL continues to grow in stature and popularity, giving an important platform for female cricketers to demonstrate their abilities on a worldwide scale. Matches such as the final between RCB and DC help to captivate fans and demonstrate the league’s tremendous competitiveness. The continued success of teams such as RCB only adds to the league’s allure and long-term viability.

Looking Ahead: A Bright Future

Maintaining Momentum

As RCB basks in the joy of winning back-to-back WPL titles, the issue now is to maintain that momentum. The cricket world will be looking to see how they evolve, innovate, and defend their championship status in the coming seasons. The benchmark has been established, and expectations are higher than ever.

The Expanding Reach of Women’s Cricket

The WPL’s success, fuelled by compelling finals and celebrity endorsements such as Anushka Sharma’s, demonstrates the growing reach and attraction of women’s cricket. It demonstrates the quality, passion, and rising fans that this format continues to attract, implying an even brighter future for the sport.

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