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Arthritis drug may improve Covid-19 survival among elderly patients, says study
A medication used to treat rheumatoid joint inflammation may diminish the danger of passing on for old patients with Covid-19, and give another weapon in the stockpile against the novel Covid, as per an investigation.
In the exploration, distributed in the diary Science Advances, 83 patients with a middle age of 81 and all experiencing moderate to extreme Covid-19 disease were given a medication called baricitinib.
This prescription was at first distinguished by researchers at Imperial College London in the UK utilizing man-made reasoning (AI) as a medication that could have against viral and mitigating impacts.
In the examination, the patients, who were in numerous emergency clinics across Italy and Spain, had a 71 percent decreased danger of kicking the bucket contrasted with patients who had not taken the medication.
The investigation found that 17 percent of patients who were given the medication passed on or expected to go on a ventilator, contrasted with 35 percent in the benchmark group who were not given the drug.
The exploration group says the discoveries are being followed up with enormous scope clinical preliminaries.
“We critically need to discover more successful medicines for Covid-19 while we trust that an antibody will turn out to be broadly accessible,” said Professor Justin Stebbing, co-lead creator of the investigation from Imperial College London.
“This is one of the main Covid-19 medicines to go from PC to center and lab. It was first distinguished by an AI calculation in February, which filtered a large number of potential medications that could neutralize this infection,” Stebbing said.
The examination proposes this medication can help recuperation of patients with moderate to extreme Covid-19, and may give another weapon in the arms stockpile against the infection, the analysts said.
The group developed smaller than normal human organs in the lab, called organoids, to examine how precisely the medication may battle Covid-19.
The discoveries uncovered that the medication may help work in two different ways: diminish organ harm brought about by aggravation, and obstructing the infection entering human cells.
At the point when tainted with the Covid-19 infection, called SARS-CoV-2, the body discharges various kinds of incendiary atoms, called chemokines and cytokines.
These atoms go about as the early notice framework for the body, telling the resistant framework the body is enduring an onslaught.
The investigation likewise recommended Covid-19 builds the movement of qualities identified with platelets, which can make the blood clingy and bound to frame clumps. The medication baricitinib was appeared to decrease the movement of the qualities.
“This investigation affirms what AI anticipated, and what we were getting with tolerant case reports. For example one case included a 87-year-old seriously unwell patient from Foggia, Italy, who demonstrated quick improvement in the wake of being given the medication, though her significant other and child, who didn’t get baricitinib, kicked the bucket,” said Professor Volker Lauschke, co-lead creator from Karolinska Institutet, Sweden.
“This investigation has likewise shone a light on precisely how this medication may secure us at the cell level. This encourages us comprehend why different kinds of medications are demonstrating gainful, or not useful, as we as help recognize different medicines which may handle Covid-19,” Lauschke said.
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Music
Winner of BTS’ Jungkook lookalike competition in Chicago is an all-too-familiar face as ‘lore runs deep’
On Sunday, The BTS Jungkook lookalike contest winner was crowned in Chicago. Impersonators sporting his signature piercings and tattoos swarmed the venue.
Social media personality Andrew Alexander, who’s previously been documented as sharing “striking similarities” with BTS’ Jungkook, won the K-pop star-focussed lookalike competition in Chicago on Sunday, November 24, 2024. (Instagram )
The chain reaction set off by YouTuber Anthony Po’s super-viral Timothée Chalamet look-alike contest in Manhattan on October 27, led fans to the K-pop chapter of this journey a month later.
On Sunday, November 24, the new US trend surrounding celebrity lookalike contests saw BTS’ Jungkook enthusiasts turning up for registration in droves. As the Hindustan Times (and several other outlets) previously reported, the event held at Ping Tom Memorial Park in Chicago, Illinois, handed out a $20 cash prize and a bottle of Soju to the winner. As it turned out, some older fans of the K-pop septet already knew the much-debated winner of the anticipated turnout.
A flurry of fan-shared videos and photos popped up online on Sunday (US time), capturing the three finalists in action as the trio, like other Jungkook impersonators showed up dressed in variations of black outfits. Ultimately, Andrew Alexander, a widely renowned YouTube sensation, was crowned the winner. Even if the name doesn’t ring a bell, some BTS fans will remember the content creator from a years-old YouTube video, in which his sister “turned” him into the beloved K-pop group’s maknae.
Who is Andrew Alexander, the winner of Chicago’s Jungkook lookalike competition?
According to the social media personality’s YouTube videos, Andrew is a third-year university student living in California. He clearly flew into Chicago, especially for the Jungkook contest scheduled this week.
Over four years ago, Alexander’s sister, Ashley, posted a video titled “I turned my brother into BTS Jungkook,” as she highlighted how “a lot of people say he looks like” the K-pop star. Given their “striking similarities,” as reflected not only their resemblance (though not validated by a lot of fans) but also their mannerisms, Andrew’s other sister (presumably), Amber, said at the time, “It’s so funny every video we post, there’s at least 20 new people that are like ‘I don’t know if anyone’s ever said this but, Andrew looks like Jungkook’”.
However, Andrew himself did not admit to the similarities. That didn’t stop BTS fan pages from drawing comparisons between him and the BTS singer.
In a video posted before the viral winning announcement, Andrew’s sister documented the scene at the competition venue. Ashley wrote confirmed in the caption, “He flew from LA we flew from NY.” Ironically, the ultimate Jungkook lookalike contest participant was also registered as #7, a number that holds great emotional significance in the BTS fandom, given the group’s member count.
A netizen who’d had been a longtime fan of the Alexander siblings clan – all YouTube personalities – commented on one of Andrew’s posts on November 24, “been a fan since 2018,” as they added a reference to Ashley’s YouTube channel “ur mom ashley.”
In yet another video posted by Amber Alexander, she also recorded the full-circle moment: “He flew all the way from California for this (crying emoji) after years of getting comments saying he looks like Jungkook @andrewalexander WON THE LOOKALIKE COMPETITION.”
Hours before show time, Ashley also took to her TikTok profile (@aaashleyk), showing a behind-the-scenes glimpse at how the family ‘Jungkook-ified’ Andrew by drawing the pop star’s famously known hand tattoos and suggesting that he needed a lip ring as well. For his final look, Andrew also showed up with Jungkook’s eyebrow and ear piercings.
Fans react to the winner being crowned for the lookalike contest
While some instantly approved the decision with comments like “Andrew is actually the ONLY one who looked like jungkook, the others literally have no similarity at all,” others who probably never tracked the siblings’ years-old digital footprints were lost why this win was especially gaining momentous traction online.
“If Andrew didn’t win, I would have hosted another one to make sure he won,” someone else wrote in the comments. Others quipped along the lines of how Jungkook had returned from the military and “Kinda crazy how they let Jungkook win his own lookalike competition.”
Those familiar with Andrew’s journey, definitely agreed with how the contest “cooked” with its final decision, especially since “the lore runs deep.” Who could’ve known that this was years in the making at a time when lookalike contests weren’t a norm?
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Winner of BTS’ Jungkook lookalike competition in Chicago is an all-too-familiar face as ‘lore runs deep’
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