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Protein partners have been found by researchers who may help to mend cardiac muscle.

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Protein partners have been found by researchers who may help to mend cardiac muscle.

The work is being carried out by researchers at the UNC School of Medicine, and could have a substantial impact on the development of future treatments for broken hearts.  Researchers have found a way to reprogram scar tissue cells (fibroblasts) to become healthy heart muscle cells. The study was published in the journal Cell Stem Cell (cardiomyocytes) Researchers are looking into possibly treating or one day curing cardiac disease.

They used a gene activity-controlling protein called Ascl1, which is well recognised to be an essential protein for converting fibroblasts into neurons. Researchers hope to use this technique to give patients injections to transform harmful cells into helpful ones. Fibroblast over-activity underlies many major diseases and conditions including heart failure, chronic obstructive pulmonary disease, liver disease, kidney disease and the scar-like brain damage that occurs after a stroke. “Reprogramming fibroblasts has long been one of the important goals in the field of stem cell therapy,” Qian says. A team of researchers led by Professor Yingying Qian has developed a way to reprogram mice fibroblasts into cardiomyocytes, liver cells, and neurons. Qian’s team studied the variations in gene activity patterns and variables that control gene activity during these three separate reprogrammings. A team of researchers has discovered that converting fibroblasts into neurons activated genes related to cardiomyocytes. Ascl1, one of the master-programmer “transcription factor” proteins, was the cause of this activation. They were shocked to see that it significantly increased reprogramming efficiency by more than ten times.

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Study: Maternal obesity more accurately predicts risk of heart disease than pregnancy issues.

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Study: Maternal obesity more accurately predicts risk of heart disease than pregnancy issues.

Maternal health during pregnancy is a critical factor in the well-being of both the mother and the child. While a range of issues can arise during pregnancy, new research suggests that maternal obesity may be a more accurate predictor of heart disease risk than specific complications during pregnancy. This study sheds light on the long-term health implications of obesity and emphasizes the importance of addressing this public health concern. In this blog, we’ll explore the findings of this study and their broader implications.

A Stronger Predictor of Heart Disease Risk than Pregnancy Complications

A recent study published in a medical journal has attracted attention for its focus on maternal obesity and its impact on future heart disease risk. Researchers conducted a retrospective analysis of medical records of women who had given birth in the past decade, tracking their health outcomes over time. The study found that maternal obesity is a more robust predictor of heart disease risk than specific pregnancy complications like gestational diabetes or pre-eclampsia.

Key Findings

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  1. Long-term Risk: The study’s findings suggest that maternal obesity is associated with a significantly higher risk of heart disease in the years following pregnancy. This highlights the importance of addressing obesity as a long-term health concern, not just a temporary condition associated with pregnancy.
  2. Preeclampsia and Gestational Diabetes: While preeclampsia and gestational diabetes are well-known complications of pregnancy that can impact maternal health, the study found that these conditions did not have as strong a correlation with future heart disease risk as maternal obesity.
  3. Weight Management: The study underscores the importance of proactive weight management for women before, during, and after pregnancy. It highlights that addressing obesity may have a more significant impact on reducing heart disease risk than solely focusing on managing specific pregnancy-related complications.

Implications

  1. Public Health Focus: Maternal obesity is a critical public health issue that extends beyond pregnancy. This research reinforces the need for society and healthcare systems to prioritize weight management and obesity prevention strategies to reduce the long-term health risks associated with obesity.
  2. Holistic Approach: Healthcare providers should consider a holistic approach to maternal health that includes not only addressing pregnancy-related issues but also focusing on a woman’s overall well-being, including weight management and cardiovascular health.
  3. Education and Support: Women planning to become pregnant or already expecting should receive information, education, and support regarding the importance of maintaining a healthy weight before and after childbirth. Health professionals can play a vital role in providing guidance and resources.

The findings of this study highlight the critical role that maternal obesity plays in predicting future heart disease risk, even more so than specific pregnancy complications. This research serves as a call to action for healthcare providers, policymakers, and society as a whole to prioritize the prevention and management of obesity to safeguard the long-term health of women and reduce their risk of heart disease. Addressing this public health issue early can lead to healthier mothers, healthier pregnancies, and ultimately healthier families.

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