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Protein partners have been found by researchers who may help to mend cardiac muscle.

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Protein partners have been found by researchers who may help to mend cardiac muscle.

The work is being carried out by researchers at the UNC School of Medicine, and could have a substantial impact on the development of future treatments for broken hearts.  Researchers have found a way to reprogram scar tissue cells (fibroblasts) to become healthy heart muscle cells. The study was published in the journal Cell Stem Cell (cardiomyocytes) Researchers are looking into possibly treating or one day curing cardiac disease.

They used a gene activity-controlling protein called Ascl1, which is well recognised to be an essential protein for converting fibroblasts into neurons. Researchers hope to use this technique to give patients injections to transform harmful cells into helpful ones. Fibroblast over-activity underlies many major diseases and conditions including heart failure, chronic obstructive pulmonary disease, liver disease, kidney disease and the scar-like brain damage that occurs after a stroke. “Reprogramming fibroblasts has long been one of the important goals in the field of stem cell therapy,” Qian says. A team of researchers led by Professor Yingying Qian has developed a way to reprogram mice fibroblasts into cardiomyocytes, liver cells, and neurons. Qian’s team studied the variations in gene activity patterns and variables that control gene activity during these three separate reprogrammings. A team of researchers has discovered that converting fibroblasts into neurons activated genes related to cardiomyocytes. Ascl1, one of the master-programmer “transcription factor” proteins, was the cause of this activation. They were shocked to see that it significantly increased reprogramming efficiency by more than ten times.

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Ratan Tata, industry titan and national icon, dies at 86

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Ratan Tata, industry titan and national icon, dies at 86

Ratan Tata, who ran Tata Sons for more than 20 years as chairman, died at a Mumbai hospital.

Ratan Tata, the chairman emeritus of Tata Sons, has died, the group announced in a statement on Wednesday. He was 86. Ratan Tata, who ran the conglomerate for more than 20 years as chairman, had been undergoing intensive care in a Mumbai hospital since Monday.

“It is with a profound sense of loss that we bid farewell to Mr. Ratan Naval Tata, a truly uncommon leader whose immeasurable contributions have shaped not only the Tata Group but also the very fabric of our nation,” said N Chandrasekaran, Chairman, Tata Sons, in a late night statement.

On Monday, the industrialist had in a social media post dismissed speculation surrounding his health and had said he was undergoing routine medical investigations due to his age.

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Prime Minister Narendra Modi paid tribute to Ratan Tata, calling him a visionary business leader, compassionate soul, extraordinary human being.

“Ratan Tata endeared himself to people, thanks to his humility, kindness, unwavering commitment to making society better,” PM Modi said in a post on X (formerly Twitter).

After graduating with a degree in architecture at Cornell University, he returned to India and in 1962 began working for the group his great-grandfather had founded nearly a century earlier.

He worked in several Tata companies, including Telco, now Tata Motors Ltd, as well as Tata Steel Ltd, later making his mark by erasing losses and increasing market share at group unit National Radio & Electronics Company.

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In 1991, he took the helm of the conglomerate when his uncle J.R.D. Tata stepped down – the passing of the baton coming just as India embarked on radical reforms that opened up its economy to the world and ushered in an era of high growth.

Under Tata’s leadership, the group launched the Tata Nano, the world’s cheapest car, and expanded its software services arm, Tata Consultancy Services (TCS), into a global IT leader.

Tata stepped down as chairman in 2012 but was later named chairman emeritus of Tata Sons and other group companies, including Tata Motors and Tata Steel. He briefly returned as interim chairman in 2016 during a leadership dispute.

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