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Antibodies that might neutralize Omicron identified by scientists

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Antibodies that might neutralize Omicron identified by scientists

In a recent study, an international team of scientists identified antibodies that can neutralize omicron and other SARS-CoV-2 variants.

These antibodies target areas of the viral spike protein, which remain essentially unchanged when the virus mutates. The results of the study were published in the journal Nature.

David Veesler said that by identifying the targets of these “broadly neutralizing” antibodies on the spike protein, it is possible to design vaccines and antibody treatments that are effective not only for the omicron variant but also for other variants that may appear in the future. Researcher at the Howard Hughes Medical Institute and associate professor of biochemistry at the University of Washington School of Medicine in Seattle.

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Also read: As Omicron advances Covid-19 cases, will 2022 be different?

“This discovery tells us that by focusing on antibodies against these highly conserved sites on the spike protein, there is a way to overcome the continuous evolution of the virus,” Wesseler said. Vir Biotechnology, in Switzerland. The lead authors of the study are Elisabetta Cameroni and Christian Saliba (Humabs), John E. Bowen (University of Washington Biochemistry) and Laura Rosen (Vir).

The omicron variant has 37 mutations in the spike protein, which is used to lock and invade cells. This is an unusually large number of mutations. It is believed that these changes partly explain why the variant can spread so quickly, thereby infecting people who have been vaccinated and reinfecting people who were previously infected.

“The main question we are trying to answer is: How does this series of mutations in the spike protein of the omicron variant affect its ability to bind to cells and evade immune system antibody responses,” Veesler said. Veesler and his colleagues speculate that a large number of omicron mutations may have accumulated during long-term infection in people with weakened immune systems, or accumulated during the spread of the virus from humans to animal species and then back. ]

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To assess the impact of these mutations, the researchers designed a disabling, non-replicating virus called a pseudovirus, which produces spike proteins on its surface, just like a coronavirus. They then created pseudoviruses with spike proteins with omicron mutations, as well as those found in the earliest variants found in the pandemic.

The researchers first observed how different versions of the spike protein bind to the protein on the cell surface, which the virus uses to attach and enter the cell. This protein is called the angiotensin converting enzyme 2 (ACE2) receptor.

Complete News Source : Hindustan Times

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DTC to start electric buses from 3 Delhi ISBTs to Noida airport by May end

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DTC to start electric buses from 3 Delhi ISBTs to Noida airport by May end

The buses will start and currently serve Greater Noida and Jewar, even though the airport is probably not going to be operational by May By the end of May, the Delhi Transport Corporation (DTC) plans to begin operating electric buses from the Capital to the soon-to-be Noida International Airport (NIA) in Jewar, according to officials. The buses will begin at.

Delhi’s three Inter State Bus Terminals (ISBTs) — Maharana Pratap ISBT at Kashmere Gate, Swami Vivekanand ISBT at Anand Vihar, and Veer Hakikat Rai ISBT at Sarai Kale Khan — and currently serve Greater Noida and Jewar, even though the airport is probably not going to meet the May deadline to be operational The Delhi Transport Corporation (DTC) is set to launch.

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Electric bus services connecting Delhi’s Inter-State Bus Terminals (ISBTs) to the upcoming Noida International Airport (NIA) in Jewar by the end of May 2025. This initiative aims to enhance connectivity between the national capital and the new airport, providing a March 2025, DTC and NIA signed operate thesesustainable and efficient mode transportation for.

Key Features of the Service

  • Routes and Terminals: The electric buses will operate from three major ISBTs in Delhi: Maharana Pratap ISBT at Kashmere Gate, Swami Vivekanand ISBT at Anand Vihar, and Veer Hakikat Rai ISBT at Sarai Kale Khan. Initially, these buses will serve areas in Greater Noida and Jewar, catering to the March 2025, DTC and NIA signed an MoU to operate these demand for public transport in these regions.
  • Memorandum of Understanding (MoU): In March 2025, DTC and NIA signed an MoU to operate these bus services, formalizing the collaboration between the two entities The fleet will consist of air-conditioned, low-floor electric buses equipped with modern amenities, including GPS tracking, CCTV cameras, panic buttons, and broad aisle spaces to accommodate luggage. These features aim to ensure.
  • Commuters passenger safety and comfort during transit While the exact fare amounts are yet to be finalized, discussions are ongoing in consultation with the Yamuna Expressway Industrial Development Authority (Yeida), which manages the Jewar area. The authorities aim to establish a cost-effective fare structure for commuters The bus services will initially be deployed on a pilot basis. Depending demand.

Additional Considerations

  • Infrastructure Development: A four-kilometer stretch of road that will be part of the bus route is not fully developed yet. DTC has reached out to Yeida to ascertain the usability and development timeline of this segment to ensure seamless operations. and passenger feedback, routes may be adjusted, and the number of buses increased to better serve commuters this, the bus services will begin as scheduled.
  • Airport Operational Timeline: Although the NIA was expected to commence operations by mid-May 2025, it is likely to miss this deadline due to ongoing construction work. Despite this, the bus services will begin as scheduled, providing connectivity to the surrounding areas in the interim providing connectivity to the surrounding areas in the interi This initiative reflects DTC’s commitment to.
  • Enhancing public transportation infrastructure and promoting eco-friendly travel options in the National Capital Region. By introducing electric buses on this route, the corporation aims to offer a reliable and sustainable alternative for commuters traveling between Delhi and the upcoming Noida International The Delhi Transport Corporation (DTC) is set to commence electric bus services.
  • connecting Delhi’s Inter-State Bus Terminals (ISBTs) to the upcoming Noida International Airport (NIA) in Jewar by the end of May 2025. This initiative aims to provide eco-friendly and convenient transportation options for commuters traveling between Delhi and the new airport NIA was expected to commence.
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