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Are Omicron-specific vaccines any better than original jabs? What early tests show

Published

3 years ago

on

Are Omicron-specific vaccines any better than original jabs? What early tests show

Early animal studies by scientists around the world found that Omicron’s specific coronavirus vaccine booster was no better at preventing infection than previously available boosters. The Omicron variant of Covid-19 still dominates the world and is by far the most transmitted strain.

Numerous studies have been conducted to determine whether a third dose of the vaccine is sufficient to build immunity to Omicron. Leading vaccine makers Pfizer and Moderna also announced earlier that they had begun clinical trials of their Omicron-specific shots.

David Montefiori, director of the AIDS Vaccine Laboratory, said: “What we’ve seen from these preclinical studies in animal models is that boosting with the mutant vaccine did not compare to boosting with the existing vaccine. It works better,” said researchers and developers at Duke University Medical Center in Durham, North Carolina, in an interview with Nature.

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A report in the journal said that most of the early studies involved small groups of animals, all of which suggested that customized vaccine boosters would not change anything against Omicron. These studies have not been peer-reviewed.

According to the report, a study examined immune responses in rhesus monkeys, a type of monkey, with just eight primates, two doses of Moderna’s original vaccine and a booster shot of the same dose or a specific version of Omicron. The researchers found that monkeys boosted with both vaccines exhibited broad antibody responses to all variants of interest, including Omicron.

However, the study only examined responses up to 4 weeks, meaning it’s unclear how long the vaccine’s efficacy will last.

In another study, scientists tested a “replicating RNA” vaccine in mice. They obtained three doses of the replicating RNA vaccine — two based on the ancestral SARS-CoV-2 strain, followed by a single Omicron-specific booster — made by HDT Bio in Seattle, Washington, the report said.

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Complete News Source : Hindustan Times

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Day 6 box office receipts for Game Changer: Ram Charan’s film takes another hit, earning over ₹110 crore

Published

6 days ago

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January 16, 2025

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Day 6 box office receipts for Game Changer: Ram Charan’s film takes another hit, earning over ₹110 crore

Game Changer box office collection day 6: Ram Charan and Kiara Advani-starrer released in theatres on January 10.
Game Changer box office collection: Ram Charan, Kiara Advani-Game Changer is one the first big releases of this year, and came with huge audience expectations. However the film opened to mixed reviews and has performed decently at the box office. As per the latest version of Sacnilk.com, Game Changer has minted ₹6.11 crore in its sixth day of release. Game Changer is directed by Shankar.

Game Changer box office collection

The report states that Game Changer has now crossed the ₹110 crore mark at the box office. It minted ₹5.55 crore on its first Wednesday, which is the lowest for the film so far. The film had seen a slight growth on its fifth day of release, with ₹10 crore net. The overall collections now stand at ₹112.26 crore.

Game Changer minted ₹51 crore on its opening day, and saw a dip in collections on its second day with ₹21.6 crore. Day three collections were at ₹15.9 crore whereas day four net was ₹7.65 crore. The film saw a sharp decline in its weekdays and is yet to recover. Game Changer is facing stiff competition from a number of releases, which includes Nandamuri Balakrisha’s Daaku Maharaj, Unni Mukundan’s Marco and Allu Arjun’s Pushpa 2: The Rule.

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More details

Amid box office concerns for the film, a pirated version of Game Changer was allegedly aired on a local TV channel and shown in buses. Screenshots of the same surfaced on X, which caught the attention of producer Sreenivas Kumar. He took to his X account to demand strict action on it.

A few days ago, the makers of the film had filed a complaint against individuals for allegedly leaking a pirated version of the film online. The complaint also states that before the film’s release, the producers and a few team members were threatened through social media and messaging platforms like WhatsApp, wherein the same alleged pirates demanded money from producers and threatened to leak the pirated version if their demands were not fulfilled.

Game Changer is directed by Shankar and stars Ram Charan, Kiara Advani, and SJ Suryah. The film has also been released in Tamil, Kannada, and Malayalam.

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