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Combinations of medications may aid in reducing the progression of diabetic kidney damage



Combinations of medications may aid in reducing the progression of diabetic kidney damage

Combining SGLT2 inhibitors — a newer class of diabetes treatments that reduces blood sugar — with older diabetes meds may help to halt the onset of diabetic kidney impairment, according to a mouse study led by Washington University School of Medicine in St. Louis. Dapagliflozin (Farxiga), empagliflozin (Jardiance), and canagliflozin (Canagliflozin) are some of the most commonly prescribed SGLT2 inhibitors (Invokana).

Kidney disease is the largest cause of death in the United States, impacting 37 million people, many of whom are unaware that their kidneys are failing. There is no cure, and the only therapies for end-stage renal disease are dialysis and kidney transplantation.

A mouse study headed by Washington University School of Medicine in St. Louis reveals that combining SGLT2 inhibitors — a newer class of diabetes treatments that reduces blood sugar — with older diabetes drugs may help to halt the course of diabetic kidney impairment.


Dapagliflozin (Farxiga), empagliflozin (Jardiance), and canagliflozin (Canagliflozin) are some of the most commonly prescribed SGLT2 inhibitors (Invokana). Janssen Pharmaceuticals, whose experts cooperated on this study, produces the latter.

Diabetic kidney disease affects roughly 40% of type 2 diabetes patients, resulting in renal failure, cardiovascular disease, and early death. Diabetes, renal disease, and kidney failure are more common in African Americans, Native Americans, and Hispanics than in Caucasians.

Diabetes harms the kidneys by preventing them from filtering waste and extra fluids from the body adequately. Most people don’t recognise they have kidney disease until irreversible organ damage occurs since symptoms including nausea, vomiting, sleep difficulties, and swelling limbs are common and nonspecific.

SGLT2 inhibitors, also known as sodium-glucose cotransporter-2 inhibitors, cause the kidneys to excrete excess sugar from the blood, which is then excreted through urine. Humphreys, who is also the Joseph Friedman Professor of Renal Diseases in Medicine, added, “This family of medications is also very protective for heart disease.”


Although most patients with type 2 diabetes are prescribed only one medicine, the findings of this study show that combination therapy may be more successful since different drug classes target different cell types in the kidney.

The researchers examined how mouse kidneys respond to five diabetes therapy regimens administered to people using mice that had developed diabetic kidney damage. The researchers used single-cell RNA sequencing to look for alterations in the kidneys at the cellular and molecular level as a result of the various therapies. Researchers can use this knowledge to better target certain cells in order to improve medication therapy.

They focused on the impact of three kinds of drugs: SGLT2 inhibitors, angiotensin converting enzyme inhibitors (ACE inhibitors), such as Lisinopril, and Thiazolidinediones (TZD, also known as insulin sensitizers). A common TZD is rosiglitazone.

The study’s first author, Haojia Wu, PhD, an assistant professor in the Division of Nephrology, said, “We structured this study to try to understand how combination medicines affect the kidney differently than single therapies.” “We discovered that each of the distinct classes of medications targeted different cell types, offering a biological justification for combination therapy to help diabetic kidney disease advance more slowly.”


The study discovered that combining SGLT2 inhibitors with Lisinopril showed superior kidney protection than either of the standalone treatments.

SGLT2 inhibitors also appeared to mislead the kidney into initiating a starvation response, similar to how the body slows down its metabolism while fasting for long periods of time, according to the researchers.

This could lower the kidney’s overall energy consumption, allowing it to perform more efficiently and putting less strain on it in the long run, which could explain why this family of medications is so effective,” Humphreys added.

“Treatments for diabetic kidney disease are at an all-time high,” he noted. “Our research adds to the growing body of data that combining medicines has significant benefits for patients.” Such techniques, we believe, should be used in ordinary clinical practise.”


Future observational studies in persons using combo medicines, according to Humphreys, should provide more data.        Group Media Publications
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10 best activities hacks for the better lifestyle for Computer Operators.




10 best activities hacks for the better lifestyle for Computer Operators.

In today’s digital age, computer operators play a crucial role in various industries, spending extended hours in front of screens to ensure smooth operations. However, this sedentary lifestyle can take a toll on their physical and mental well-being. To combat the challenges posed by long hours of computer use, we have compiled a list of 10 best activity hacks to promote a healthier and more balanced lifestyle for computer operators.

lifestyle for Regular Eye Breaks

The first and foremost activity hack is to encourage computer operators to take regular eye breaks. Every hour, remind them to look away from the screen and focus on a distant object for 20-30 seconds. This simple practice helps reduce eye strain and prevent computer vision syndrome.

Create Ergonomic Workstations

Investing in ergonomic workstations is vital to safeguard the health of computer operators. Adjustable chairs, keyboards, and monitors ensure proper posture, minimizing the risk of musculoskeletal issues like neck and back pain.

Incorporate Stretching Exercises

Introduce quick and effective stretching exercises that target areas prone to tension—neck, shoulders, wrists, and back. Encourage computer operators to take short stretching breaks, enhancing flexibility and reducing the likelihood of repetitive strain injuries.

Engage in Fitness Challenges

Organize fitness challenges that inspire computer operators to integrate physical activity into their daily routines. Step count contests or stair-climbing challenges can encourage movement and boost overall fitness levels.

Practice Mindfulness for Mental Breaks

Promote mindfulness and relaxation techniques, such as meditation or deep breathing exercises, during breaks. These activities help reduce stress levels, enhance focus, and improve overall mental well-being.

Offer Healthy Snack Options

Support healthy eating habits by providing nutritious snack options in the workplace. Fruits, nuts, and yogurt can be excellent alternatives to sugary or processed snacks, ensuring sustained energy levels throughout the day.

Foster Knowledge Sharing Sessions

Organize workshops or knowledge-sharing sessions on topics like time management, stress reduction, and personal development. These sessions not only enrich computer operators’ skills but also contribute to a positive work environment.

Implement Flexible Work Schedules

Offer flexible work arrangements to enable computer operators to balance their professional and personal lives effectively. Flexibility empowers them to take care of their well-being without compromising on productivity.

Cultivate Social Connections

Foster a sense of camaraderie among computer operators by organizing team-building activities and social events. Building meaningful relationships within the workplace positively impacts motivation and job satisfaction.

Support Skill Development

Provide opportunities for skill development and career advancement relevant to computer operators’ roles. Training and learning programs not only enhance their knowledge but also boost confidence and job engagement.

By implementing these 10 activity hacks, companies can transform the lifestyles of computer operators for the better. Prioritizing their physical health, mental well-being, and personal development creates a happier, more productive, and motivated workforce. Empowering computer operators with the tools and resources for a healthier lifestyle not only benefits them as individuals but also leads to increased efficiency and success in the digital workspace. Together, let’s work towards cultivating a healthier, happier future for computer operators and all professionals in the digital era.

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