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DRDO issues directions for the usage of anti-Covid drug 2-DG on patients

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DRDO issues directions for the usage of anti-Covid drug 2-DG on patients

The Defense Research and Development Organization (DRDO) on Tuesday issued guidelines on how and when to use its anti-Covid drug 2-deoxy-D-glucose (2-DG) drug.

The drug was launched by the Defense Ministry last month. It has been developed by the Institute of Nuclear Medicine and Allied Sciences (INMAS), a premier laboratory of DRDO, in collaboration with Dr Reddy’s Laboratories (DRL) in Hyderabad.

DRDO said that the 2-DG drug should be used under the supervision of a doctor. Oral medication for emergency use is an adjunctive therapy for the treatment of severe COVID patients. It reduces dependence on supplemental oxygen.

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2-DG. Directions for use:

  1. 2DG should be prescribed by doctors early. The drug can be prescribed for up to 10 days and the recipients can be both moderate to severe COVID patients.
  2. This drug is approved for ’emergency use’, and can be used as adjunctive therapy along with the standard procedure followed in the treatment of a COVID patient.
  3. 2DG has not yet been tested in patients with uncontrolled diabetes, severe cardiac problems, ARDS, severe hepatic and renal impairment. So extra caution is needed.
  4. Lactating and pregnant women should not be prescribed with 2DG, and the same applies to people under 18 years of age.
  5. Patients/attendants wishing to purchase 2DG medicine should email their requirements to 2DG@drreddys.com. This email id belongs to Dr. Reddy’s Lab, Hyderabad.

The drug was approved by the Drug Controller General of India (DCGI) on May 1 for emergency use as adjunctive therapy in moderate to severe COVID-19 patients. Defense Minister Rajnath Singh and Health Minister Harsh Vardhan released the first batch of indigenously developed anti-COVID-19 drugs on 17 May.

The price of DRDO’s 2DG anti-COVID-19 drug has been fixed by pharma major Dr. Reddy’s Laboratories at Rs 990 per pouch. However, the medicine will be made available by the government hospitals at a subsidized price. According to Dr. Reddy’s Laboratories, the drug will be launched commercially in mid-June.

News Source: HindustanTimes

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Day 6 box office receipts for Game Changer: Ram Charan’s film takes another hit, earning over ₹110 crore

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Day 6 box office receipts for Game Changer: Ram Charan’s film takes another hit, earning over ₹110 crore

Game Changer box office collection day 6: Ram Charan and Kiara Advani-starrer released in theatres on January 10.
Game Changer box office collection: Ram Charan, Kiara Advani-Game Changer is one the first big releases of this year, and came with huge audience expectations. However the film opened to mixed reviews and has performed decently at the box office. As per the latest version of Sacnilk.com, Game Changer has minted ₹6.11 crore in its sixth day of release. Game Changer is directed by Shankar.

Game Changer box office collection

The report states that Game Changer has now crossed the ₹110 crore mark at the box office. It minted ₹5.55 crore on its first Wednesday, which is the lowest for the film so far. The film had seen a slight growth on its fifth day of release, with ₹10 crore net. The overall collections now stand at ₹112.26 crore.

Game Changer minted ₹51 crore on its opening day, and saw a dip in collections on its second day with ₹21.6 crore. Day three collections were at ₹15.9 crore whereas day four net was ₹7.65 crore. The film saw a sharp decline in its weekdays and is yet to recover. Game Changer is facing stiff competition from a number of releases, which includes Nandamuri Balakrisha’s Daaku Maharaj, Unni Mukundan’s Marco and Allu Arjun’s Pushpa 2: The Rule.

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More details

Amid box office concerns for the film, a pirated version of Game Changer was allegedly aired on a local TV channel and shown in buses. Screenshots of the same surfaced on X, which caught the attention of producer Sreenivas Kumar. He took to his X account to demand strict action on it.

A few days ago, the makers of the film had filed a complaint against individuals for allegedly leaking a pirated version of the film online. The complaint also states that before the film’s release, the producers and a few team members were threatened through social media and messaging platforms like WhatsApp, wherein the same alleged pirates demanded money from producers and threatened to leak the pirated version if their demands were not fulfilled.

Game Changer is directed by Shankar and stars Ram Charan, Kiara Advani, and SJ Suryah. The film has also been released in Tamil, Kannada, and Malayalam.

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