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India’s first coronavirus vaccine: Here is everything we know about its development

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India’s first coronavirus vaccine: Here is everything we know about its development

The whole world is waiting eagerly for an effective vaccine to fight the coronavirus pandemic. It has not only claimed lives, but also impacted people, both physically and mentally. There are more than 170 vaccines in progress right now, but closer home we have our hopes pinned on India’s first vaccine called Covaxin.

Under normal circumstances, researchers and scientists take years before formulating and releasing a vaccine, however, the global impact of COVID on humankind has pressed a ‘forward’ button on all vaccines, where it is safe to expect a vaccine in the next 4-5 months (within a span of 12-18 months).

Covaxin, the vaccine candidate developed by Bharat Biotech in collaboration with Indian Council of Medical Research (ICMR) is in Phase 2 clinical trial in the country. And now the makers have sought approval from drug regulators to start the third phase clinical trial. As per reports, the Drugs Controller General of India (DGCI) has asked Bharat Biotech to submit “complete safety and immunogenicity data of the phase II trial” and some clarifications before proceeding for the next stage.

The results of their animal-based trial of the vaccine were found to be favourable. “The vaccine candidate was found to generate robust immune responses. Thus, preventing infection and disease in the primates upon high amounts of exposure to live SARS-CoV-2 virus.”
The vaccine candidate has been tested in 12 hospitals across India, where volunteers between the ages of 18 and 55 participated in the trial. These volunteers had no co-morbidities. The places where the trial took place include Hyderabad, Delhi, Goa, Rohtak, Patna, Kancheepuram and Bhubaneswar, among other places.

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Once the trials are done, Bharat Biotech will be targeting a manufacturing capacity of 300 million doses. India is the largest vaccine producing country in the world and if India is able to produce an indigenous vaccine, it will help in fighting the capacity and managing the delivery capacity.

ICMR has said that the vaccine candidate will follow all global norms to produce the most effective vaccine, which may take sometime.

Tap To Explore More : TOI

Also Read : MORE THAN 62 LAKH PATIENTS RECOVERED FROM COVID-19 IN INDIA; 55,342 NEW CASES IN 24 HOURS

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Train smarter, not harder: How taking occasional breaks from gym can revolutionise your fitness routine

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Train smarter, not harder: How taking occasional breaks from gym can revolutionise your fitness routine

Taking regular breaks from intense training, like deload weeks, helps your body recover, preventing fatigue and injury, and ultimately boosts fitness gains.

When it comes to getting fit, the idea of spending hours at the gym might come to mind, but many fitness experts argue that taking a “deload week” every six to eight weeks is actually key to improving your fitness gains. A deload week involves reducing the intensity of workouts to allow the body to recover from the fatigue and muscle damage caused by intense training.

While high-intensity training helps build strength and fitness, it can also lead to muscle strain, and without adequate recovery, these gains can’t fully materialise. Deload weeks give the body much-needed rest to repair and rebuild, ensuring continued progress. (Also read: Bhagyashree swears by this super easy exercise for instant leg pain relief and better mobility. Watch how to do it )

Why recovery is key for muscle growth

According to an article by The Conversation, intense exercise can cause tiny tears in muscle fibres, leading to inflammation that requires rest or low-intensity exercise to heal. This inflammation is essential for muscle growth and fitness improvements. However, without proper recovery, muscles remain in a state of slight damage, preventing inflammation from resolving. This chronic state of inflammation can hinder muscle function, reducing oxygen efficiency and impairing performance. Giving muscles time to recover through rest ensures they repair properly and are primed for continued progress, setting us up for greater success in our fitness journey.

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Many gymgoers fear taking time off and are worried it will lead to a loss of gains. However, research shows that muscle genes have a “memory imprint,” which keeps them in a semi-prepared state. This allows muscles to respond more quickly and effectively to future training, promoting growth after a rest period. Even after extended periods of reduced intensity, up to seven weeks, muscular fitness can be restored to prime condition—and in some cases, surpass previous levels. Interestingly, recovery can occur twice as fast as it took to reach peak fitness initially, even if some strength is lost.

Taking time off from intense training is crucial to prevent muscle soreness and avoid overtraining syndrome. Overtraining occurs when the body doesn’t get enough rest, leading to prolonged fatigue, decreased performance, and mood disturbances. Symptoms develop gradually, making overtraining difficult to recognize until it’s severe. Rest is essential to avoid these issues and ensure long-term progress in training.

Role of overtraining syndrome and deload weeks

Overtraining syndrome is challenging to quantify due to its vague symptoms. Studies suggest it may affect as few as 10% of elite athletes, though rates could climb to 60% among highly competitive individuals. Recovery is essential for both fitness and overall health. When engaging in heavy gym routines, it’s vital to incorporate sufficient recovery time into your workout plan. Unlike rest days, which involve little to no exercise once or twice a week, deload weeks feature lighter training at reduced intensity—typically about 50% fewer workouts or a 20% drop in workout intensity.

Both rest days and deload weeks are essential for recovery and crucial to improving fitness. It’s not about choosing one over the other—they complement each other. For instance, intense training for marathons, Ironman, or CrossFit competitions requires weekly rest days alongside scheduled deload weeks. However, for recreational gym-goers exercising 1–3 times weekly at a moderate intensity, the recovery from this routine is often sufficient without the need for additional deload weeks.

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Fitness influencers recommend incorporating deload weeks into training schedules every 4–8 weeks, aligning closely with the expert advice of 4–6 weeks. However, it’s crucial to listen to your body and schedule deload weeks as needed. If your performance plateaus or worsens, it may signal time for a deload. Training plans should be flexible enough to allow rest when required. Deload weeks not only enhance performance but also support overall health.

Disclaimer: This article is for informational purposes only and not a substitute for professional medical advice. Always seek the advice of your doctor with any questions about a medical condition.

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