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Is Omicron ‘subvariant’ more virulent? Concerns over BA.2 as India reports 530 samples to GISAID

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Is Omicron ‘subvariant’ more virulent? Concerns over BA.2 as India reports 530 samples to GISAID

British health authorities have identified hundreds of cases of the latest version of the Omicron variant, known as BA.2, amid concerns about its transmissibility. Due to the increasing number of domestic and foreign BA.2 sequences, the UK Health Safety Agency (UKHSA) has designated the Omicron variant sublineage as a variant under investigation.

To date, 426 cases of Omicron BA.2 have been confirmed in the UK by whole genome sequencing (WGS), with the earliest case reported on 6 December 2021. Of these, 146 were confirmed BA-2 cases. The largest number of Omicron sub-variants reported in London is the UK, followed by the South East (97).

While uncertainty remains about the significance of the viral genome changes, earlier analysis by UKHSA showed an increase in growth rates compared to the original Omicron lineage BA.1.

“[H] However, in the early stages of variation, the certainty of growth rates is lower and requires further analysis,” the health agency added.

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A total of 40 countries have reported 8,040 Omicron sublineage sequences to GISAID, the leading source for open-access influenza and coronavirus genome data. The first sequences were submitted from the Philippines. To date, most samples for BA-.2 have been uploaded from Denmark, with a total of 6,411 sequences. India reported 530 samples of Omicron subvariants, followed by Sweden with 181 and Singapore with 127. Is it more toxic?

UKHSA’s Director of Covid-19 Events Dr Meera Chand said the nature of viruses was to evolve and mutate, so new variants were expected as the pandemic continued.

“To date, there is insufficient evidence to determine whether BA.2 causes more severe disease than Omicron BA.1, but data are limited and UKHSA is continuing to investigate,” Chand said.

French epidemiologist Antoine Flahault expressed surprise at the rapid spread of the Omicron sub-variant in Denmark, according to AFP.

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“(France) expected a spike in pollution in mid-January: it didn’t happen, maybe because of this sub-variant, which seems to spread easily, but is no more virulent than BA.1,” he said, stressing that countries As scientists step up monitoring, it is imperative to remain vigilant about the latest developments.

Citing early observations in India and Denmark, virologist Tom Peacock of Imperial College London said there was no significant difference in severity compared with BA.1.

In a series of tweets, he stressed that “we don’t have a strong control at this time…how much transmission capacity BA.2 might have over BA.1. However, we can make some guesses/early observations.”

The latest variant should not question the effectiveness of existing vaccines, he added.

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Complete News Source : Hindustan Times

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Train smarter, not harder: How taking occasional breaks from gym can revolutionise your fitness routine

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Train smarter, not harder: How taking occasional breaks from gym can revolutionise your fitness routine

Taking regular breaks from intense training, like deload weeks, helps your body recover, preventing fatigue and injury, and ultimately boosts fitness gains.

When it comes to getting fit, the idea of spending hours at the gym might come to mind, but many fitness experts argue that taking a “deload week” every six to eight weeks is actually key to improving your fitness gains. A deload week involves reducing the intensity of workouts to allow the body to recover from the fatigue and muscle damage caused by intense training.

While high-intensity training helps build strength and fitness, it can also lead to muscle strain, and without adequate recovery, these gains can’t fully materialise. Deload weeks give the body much-needed rest to repair and rebuild, ensuring continued progress. (Also read: Bhagyashree swears by this super easy exercise for instant leg pain relief and better mobility. Watch how to do it )

Why recovery is key for muscle growth

According to an article by The Conversation, intense exercise can cause tiny tears in muscle fibres, leading to inflammation that requires rest or low-intensity exercise to heal. This inflammation is essential for muscle growth and fitness improvements. However, without proper recovery, muscles remain in a state of slight damage, preventing inflammation from resolving. This chronic state of inflammation can hinder muscle function, reducing oxygen efficiency and impairing performance. Giving muscles time to recover through rest ensures they repair properly and are primed for continued progress, setting us up for greater success in our fitness journey.

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Many gymgoers fear taking time off and are worried it will lead to a loss of gains. However, research shows that muscle genes have a “memory imprint,” which keeps them in a semi-prepared state. This allows muscles to respond more quickly and effectively to future training, promoting growth after a rest period. Even after extended periods of reduced intensity, up to seven weeks, muscular fitness can be restored to prime condition—and in some cases, surpass previous levels. Interestingly, recovery can occur twice as fast as it took to reach peak fitness initially, even if some strength is lost.

Taking time off from intense training is crucial to prevent muscle soreness and avoid overtraining syndrome. Overtraining occurs when the body doesn’t get enough rest, leading to prolonged fatigue, decreased performance, and mood disturbances. Symptoms develop gradually, making overtraining difficult to recognize until it’s severe. Rest is essential to avoid these issues and ensure long-term progress in training.

Role of overtraining syndrome and deload weeks

Overtraining syndrome is challenging to quantify due to its vague symptoms. Studies suggest it may affect as few as 10% of elite athletes, though rates could climb to 60% among highly competitive individuals. Recovery is essential for both fitness and overall health. When engaging in heavy gym routines, it’s vital to incorporate sufficient recovery time into your workout plan. Unlike rest days, which involve little to no exercise once or twice a week, deload weeks feature lighter training at reduced intensity—typically about 50% fewer workouts or a 20% drop in workout intensity.

Both rest days and deload weeks are essential for recovery and crucial to improving fitness. It’s not about choosing one over the other—they complement each other. For instance, intense training for marathons, Ironman, or CrossFit competitions requires weekly rest days alongside scheduled deload weeks. However, for recreational gym-goers exercising 1–3 times weekly at a moderate intensity, the recovery from this routine is often sufficient without the need for additional deload weeks.

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Fitness influencers recommend incorporating deload weeks into training schedules every 4–8 weeks, aligning closely with the expert advice of 4–6 weeks. However, it’s crucial to listen to your body and schedule deload weeks as needed. If your performance plateaus or worsens, it may signal time for a deload. Training plans should be flexible enough to allow rest when required. Deload weeks not only enhance performance but also support overall health.

Disclaimer: This article is for informational purposes only and not a substitute for professional medical advice. Always seek the advice of your doctor with any questions about a medical condition.

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