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Malaria vaccines may improve with new information on naturally acquired immunity

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3 years ago

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Malaria vaccines may improve with new information on naturally acquired immunity

Scientists all over the world are trying to understand malaria parasite infections to combat them. Researchers at the University of Copenhagen have taken an important step because they discovered an important difference between naturally acquired immunity and immunity after vaccination. The results of the study were published in the journal Nature Communications.

“The antibodies produced by the body when infected with malaria look different from the antibodies produced by the body when vaccinated. This may mean that when we are naturally infected, our immune system has a more effective response to malaria vaccine than when we are naturally infected,” Said Lars Hviid, a professor in the Department of Immunology and Microbiology.

The immune system can trigger various mechanisms to protect the body. The usual defenses against parasites, viruses and bacterial infections consist of so-called macrophages. “When we are attacked from the outside, the immune system produces antibodies that attach to foreign objects that need to be resisted. They are then recognized by small cells called macrophages, which are attracted by antibodies and eat bacteria or viruses. This is basically how immunity to most infectious diseases works,” Lars Hviid explained.

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However, now, researchers have found that immunity to malaria seems to be different. Here, the body’s immune system uses some other types of cells to fight against malaria parasite infections. “We found that antibodies look different, depending on whether you have been vaccinated or infected. This means that the body activates some other defense mechanism because it uses what we call natural killer cells,” Lars Hviid said. Researchers generally believe that natural killer cells are one of the body’s best weapons against cancer cells.

However, it now appears that the defense against malaria and the immune system against cancer have common characteristics. “In layman’s terms, you can say that the immune system’s defenses against malaria are more targeted than other typical infections. Maybe we evolved in this way because it is a contagious and deadly disease-it’s hard to guess. ,” Lars Hevid said.

The researchers made this finding by comparing blood samples from Ghanaians infected with malaria with blood samples from people participating in a phase 1 clinical trial of an experimental malaria vaccine. He explained that the new knowledge can be used to develop new and improved malaria vaccines.

“Our research points to new strategies for developing better malaria vaccines in the future. Because, now, we know how the body uses natural killer cells to mobilize defenses, and we can use vaccines to imitate them,” he said.

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News Source : Hindustan Times

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Archana Puran Singh fractures wrist, apologises to Rajkummar Rao for leaving shoot midway

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3 weeks ago

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January 30, 2025

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Archana Puran Singh fractures wrist, apologises to Rajkummar Rao for leaving shoot midway

Archana Puran Singh, a Bollywood actor, was injured during a film shoot in Mumbai. She fractured her wrist during the shoot and was taken to Nanavati Max Super Speciality Hospital. Singh apologised to Rajkummar Rao for leaving the shoot midway and expressed her gratitude for the surgery.

She also shared the visible swelling around her lips and the lessons she learned from the incident. Singh was discharged after the surgery and is now back at work. She was last seen in Vicky Vidya Ka Woh Wala Video, which starred Rajkummar Rao, Triptii Dimri, Mallika Sherawat, and Vijay Raaz. The film failed to perform well at the box office, collecting only ₹58.03 crore worldwide.

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Veteran actress Archana Puran Singh recently suffered a wrist fracture while shooting for her upcoming film alongside actor Rajkummar Rao. The incident occurred around 5 a.m. on the film set, leading to immediate medical attention. She was promptly taken to Nanavati Max Super Specialty Hospital in Vile Parle, Mumbai, where she underwent surgery for the injury.

Rajkummar Rao, known for his versatility and dedication to his craft, has expressed his concern and support for Archana during this challenging time. The two actors share a professional camaraderie, having previously collaborated on various projects. Their mutual respect and understanding have been evident in their past interactions.

Archana Puran Singh, a seasoned actress and television personality, has been a prominent figure in the Indian entertainment industry for decades. She is widely recognized for her roles in films such as “Kuch Kuch Hota Hai,” “Maine Pyaar Kiya,” and “Baadshah.”

In addition to her film career, she is a beloved judge on the popular television show “The Kapil Sharma Show,” She was promptly taken to for the injury. where her infectious laughter and warm demeanor have won the hearts of audiences.

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Rajkummar Rao, on the other hand, has established himself as one of the most talented actors of his generation. His performances in films like “Newton,” “Stree,” and “Roohi” have garnered critical acclaim and numerous awards. Known for his commitment to diverse roles and his ability to bring depth to his characters, Rajkummar continues to be a significant presence in the Indian film industry.

The upcoming film featuring Archana Puran Singh and Rajkummar Rao has generated considerable excitement among fans and industry insiders. Details about the film’s plot and release date are currently under wraps, but the collaboration between these two esteemed actors has piqued interest.

In the meantime, Archana is focusing on her recovery, following medical advice and undergoing necessary physiotherapy sessions. She has expressed gratitude for the support and well-wishes from her fans and colleagues. Her resilience and positive attitude during this period are commendable, and she remains committed to returning to work once she has fully healed.

The incident serves as a reminder of the physical demands and risks associated with the entertainment industry. It highlights the importance of safety measures on set and the need for prompt medical attention in case of injuries. Both Archana and Rajkummar have demonstrated professionalism and dedication, ensuring that the production continues smoothly despite the unforeseen circumstances.

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Fans eagerly await updates on Archana’s recovery and the progress of the film. The collaboration between these two talented actors is anticipated to bring a compelling and engaging story to the screen, further enriching the Indian film landscape.

For more insights into Archana Puran Singh’s journey and her experiences in the entertainment industry, you can watch the following video

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