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Malaria vaccines may improve with new information on naturally acquired immunity

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4 years ago

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Malaria vaccines may improve with new information on naturally acquired immunity

Scientists all over the world are trying to understand malaria parasite infections to combat them. Researchers at the University of Copenhagen have taken an important step because they discovered an important difference between naturally acquired immunity and immunity after vaccination. The results of the study were published in the journal Nature Communications.

“The antibodies produced by the body when infected with malaria look different from the antibodies produced by the body when vaccinated. This may mean that when we are naturally infected, our immune system has a more effective response to malaria vaccine than when we are naturally infected,” Said Lars Hviid, a professor in the Department of Immunology and Microbiology.

The immune system can trigger various mechanisms to protect the body. The usual defenses against parasites, viruses and bacterial infections consist of so-called macrophages. “When we are attacked from the outside, the immune system produces antibodies that attach to foreign objects that need to be resisted. They are then recognized by small cells called macrophages, which are attracted by antibodies and eat bacteria or viruses. This is basically how immunity to most infectious diseases works,” Lars Hviid explained.

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However, now, researchers have found that immunity to malaria seems to be different. Here, the body’s immune system uses some other types of cells to fight against malaria parasite infections. “We found that antibodies look different, depending on whether you have been vaccinated or infected. This means that the body activates some other defense mechanism because it uses what we call natural killer cells,” Lars Hviid said. Researchers generally believe that natural killer cells are one of the body’s best weapons against cancer cells.

However, it now appears that the defense against malaria and the immune system against cancer have common characteristics. “In layman’s terms, you can say that the immune system’s defenses against malaria are more targeted than other typical infections. Maybe we evolved in this way because it is a contagious and deadly disease-it’s hard to guess. ,” Lars Hevid said.

The researchers made this finding by comparing blood samples from Ghanaians infected with malaria with blood samples from people participating in a phase 1 clinical trial of an experimental malaria vaccine. He explained that the new knowledge can be used to develop new and improved malaria vaccines.

“Our research points to new strategies for developing better malaria vaccines in the future. Because, now, we know how the body uses natural killer cells to mobilize defenses, and we can use vaccines to imitate them,” he said.

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News Source : Hindustan Times

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DTC to start electric buses from 3 Delhi ISBTs to Noida airport by May end

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2 weeks ago

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May 10, 2025

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DTC to start electric buses from 3 Delhi ISBTs to Noida airport by May end

The buses will start and currently serve Greater Noida and Jewar, even though the airport is probably not going to be operational by May By the end of May, the Delhi Transport Corporation (DTC) plans to begin operating electric buses from the Capital to the soon-to-be Noida International Airport (NIA) in Jewar, according to officials. The buses will begin at.

Delhi’s three Inter State Bus Terminals (ISBTs) — Maharana Pratap ISBT at Kashmere Gate, Swami Vivekanand ISBT at Anand Vihar, and Veer Hakikat Rai ISBT at Sarai Kale Khan — and currently serve Greater Noida and Jewar, even though the airport is probably not going to meet the May deadline to be operational The Delhi Transport Corporation (DTC) is set to launch.

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Electric bus services connecting Delhi’s Inter-State Bus Terminals (ISBTs) to the upcoming Noida International Airport (NIA) in Jewar by the end of May 2025. This initiative aims to enhance connectivity between the national capital and the new airport, providing a March 2025, DTC and NIA signed operate thesesustainable and efficient mode transportation for.

Key Features of the Service

  • Routes and Terminals: The electric buses will operate from three major ISBTs in Delhi: Maharana Pratap ISBT at Kashmere Gate, Swami Vivekanand ISBT at Anand Vihar, and Veer Hakikat Rai ISBT at Sarai Kale Khan. Initially, these buses will serve areas in Greater Noida and Jewar, catering to the March 2025, DTC and NIA signed an MoU to operate these demand for public transport in these regions.
  • Memorandum of Understanding (MoU): In March 2025, DTC and NIA signed an MoU to operate these bus services, formalizing the collaboration between the two entities The fleet will consist of air-conditioned, low-floor electric buses equipped with modern amenities, including GPS tracking, CCTV cameras, panic buttons, and broad aisle spaces to accommodate luggage. These features aim to ensure.
  • Commuters passenger safety and comfort during transit While the exact fare amounts are yet to be finalized, discussions are ongoing in consultation with the Yamuna Expressway Industrial Development Authority (Yeida), which manages the Jewar area. The authorities aim to establish a cost-effective fare structure for commuters The bus services will initially be deployed on a pilot basis. Depending demand.

Additional Considerations

  • Infrastructure Development: A four-kilometer stretch of road that will be part of the bus route is not fully developed yet. DTC has reached out to Yeida to ascertain the usability and development timeline of this segment to ensure seamless operations. and passenger feedback, routes may be adjusted, and the number of buses increased to better serve commuters this, the bus services will begin as scheduled.
  • Airport Operational Timeline: Although the NIA was expected to commence operations by mid-May 2025, it is likely to miss this deadline due to ongoing construction work. Despite this, the bus services will begin as scheduled, providing connectivity to the surrounding areas in the interim providing connectivity to the surrounding areas in the interi This initiative reflects DTC’s commitment to.
  • Enhancing public transportation infrastructure and promoting eco-friendly travel options in the National Capital Region. By introducing electric buses on this route, the corporation aims to offer a reliable and sustainable alternative for commuters traveling between Delhi and the upcoming Noida International The Delhi Transport Corporation (DTC) is set to commence electric bus services.
  • connecting Delhi’s Inter-State Bus Terminals (ISBTs) to the upcoming Noida International Airport (NIA) in Jewar by the end of May 2025. This initiative aims to provide eco-friendly and convenient transportation options for commuters traveling between Delhi and the new airport NIA was expected to commence.
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