Getting old is inevitable, but scientists at the University of California San Diego (UCSD) may be one step closer to being able to delay the aging process.
A team of scientists studied aging in yeast — chosen because its cells are easily manipulated — to try and understand if different cells age at the same rate, and for the same reason.
What they found was intriguing. Even cells made of the same genetic materials and within the same environment aged in “strikingly distinct ways,” according to the scientists, who published their findings in the journal Science.
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About half of the yeast cells aged because of a gradual decline in the nucleolus, a round body located in the nucleus of a cell, the scientists learned, by using techniques including microfluidics and computer modeling.
However, the other half aged because of a dysfunction of mitochondria, which produce a cell’s energy.
Scientists said that the cells go down one of two paths — nuclear or mitochondrial — early in life, and they continue with the aging route until they ultimately decline and die.
Researchers performed further tests to understand how the cells behaved.
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“To understand how cells make these decisions, we identified the molecular processes underlying each aging route and the connections among them, revealing a molecular circuit that controls cell aging, analogous to electric circuits that control home appliances,” said Nan Hao, senior author of the study and an associate professor in UCSD’s division of biological sciences’ molecular biology section.
After modeling the “aging landscape,” the team of researchers found they could manipulate — and optimize — the process of aging, using computer simulations to reprogram the master circuit and modify its DNA.
They were then able to create a “novel aging route,” with a dramatically extended lifespan. This, researchers believe, could ultimately lead to the possibility of delaying human aging.
“This is an aging path that never existed, but because we understand how it is regulated, we can basically design or regulate a new aging path,” Hao told .
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“Our study raises the possibility of rationally designing gene or chemical-based therapies to reprogram how human cells age, with a goal of effectively delaying human aging and extending human healthspan,” Hao said in a statement.
Scientists said that they plan to test their model in complex cells, organisms, and eventually, humans, as well as testing how combinations of therapeutics and drugs could lead to further longevity.
“Aging is a fundamental biological question. We know very little about the aging process,”
When it comes to medical relevance, , “aging is related to many diseases so if we can help slow aging or promote longevity, it will be beneficial for society.”
Hema Malini took a holy dip on Mauni Amavasya, sharing a light moment with yoga guru Baba Ramdev during the event.
During the ongoing Maha Kumbh Mela 2025 in Prayagraj, a light-hearted moment between actress and BJP MP Hema Malini and yoga guru Baba Ramdev has garnered attention. The incident occurred during a holy dip in the Ganges River, a ritual observed by many devotees during the Kumbh.
As Baba Ramdev emerged from the sacred waters, he performed a vigorous hair flip to clear water from his long locks. This dramatic gesture, characteristic of his energetic persona, inadvertently splashed water towards Hema Malini, who was standing nearby. Caught off guard, Hema Malini burst into laughter, adding a spontaneous and joyful touch to the solemn occasion.
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The video capturing this candid interaction quickly spread across social media platforms, with many users appreciating the unscripted display of camaraderie between the two prominent figures. Comments highlighted the human side of public personalities, noting how such moments bridge the gap between celebrities and the general populace.
The Maha Kumbh Mela, held every 12 years, is a significant religious event attracting millions of pilgrims from around the world. This year’s gathering has seen participation from various dignitaries, spiritual leaders, and celebrities, all coming together to partake in the holy rituals.
Hema Malini, known for her illustrious career in Indian cinema and her role as a parliamentarian, has been actively participating in the events at the Kumbh. She recently recited Sanskrit shlokas and spoke on the significance of Sanatan Dharma during her address at the Maha Kumbh Sabha in Prayagraj.
During the ongoing Maha Kumbh Mela 2025 in Prayagraj, a light-hearted moment between actress and BJP MP Hema Malini and yoga guru Baba Ramdev has captured public attention. As both emerged from a holy dip in the Ganges River.
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Baba Ramdev performed a vigorous hair flip to clear water from his long locks. This energetic gesture inadvertently splashed water towards Hema Malini, who was standing nearby. Caught off guard, she burst into laughter, adding a spontaneous and joyful touch to the solemn occasion.
The video capturing this candid interaction quickly spread across social media platforms, with many users appreciating the unscripted display of camaraderie between the two prominent figures. Comments highlighted the human side of public personalities, noting how such moments bridge the gap between celebrities and the general populace.
The Maha Kumbh Mela, held every 12 years, is a significant religious event attracting millions of pilgrims from around the world. This year’s gathering has seen participation from various dignitaries, spiritual leaders, and celebrities, all coming together to partake in the holy rituals.
Hema Malini, known for her illustrious career in Indian cinema and her role as a parliamentarian, has been actively participating in the events at the Kumbh. She recently recited Sanskrit shlokas and spoke on the significance of Sanatan Dharma during her address at the Maha Kumbh Sabha in Prayagraj.
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Baba Ramdev, a renowned yoga guru and proponent of Ayurveda, to has been a prominent figure at the Kumbh, leading yoga sessions and engaging with devotees. His dynamic presence and enthusiasm have been well-received by attendees.
The shared moment between Hema Malini and Baba Ramdev serves as a reminder of the unity and shared joy that the Kumbh Mela fosters among its participants, transcending social and cultural boundaries.
For a glimpse into Hema Malini’s participation at the Maha Kumbh Sabha, you can watch the following video:
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