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Scientists may found a way to delay aging

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5 years ago

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Scientists may found a way to delay aging

Getting old is inevitable, but scientists at the University of California San Diego (UCSD) may be one step closer to being able to delay the aging process.

A team of scientists studied aging in yeast — chosen because its cells are easily manipulated — to try and understand if different cells age at the same rate, and for the same reason.

What they found was intriguing. Even cells made of the same genetic materials and within the same environment aged in “strikingly distinct ways,” according to the scientists, who published their findings in the journal Science.

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About half of the yeast cells aged because of a gradual decline in the nucleolus, a round body located in the nucleus of a cell, the scientists learned, by using techniques including microfluidics and computer modeling.

However, the other half aged because of a dysfunction of mitochondria, which produce a cell’s energy.

Scientists said that the cells go down one of two paths — nuclear or mitochondrial — early in life, and they continue with the aging route until they ultimately decline and die.

Researchers performed further tests to understand how the cells behaved.

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“To understand how cells make these decisions, we identified the molecular processes underlying each aging route and the connections among them, revealing a molecular circuit that controls cell aging, analogous to electric circuits that control home appliances,” said Nan Hao, senior author of the study and an associate professor in UCSD’s division of biological sciences’ molecular biology section.

After modeling the “aging landscape,” the team of researchers found they could manipulate — and optimize — the process of aging, using computer simulations to reprogram the master circuit and modify its DNA.

They were then able to create a “novel aging route,” with a dramatically extended lifespan. This, researchers believe, could ultimately lead to the possibility of delaying human aging.

“This is an aging path that never existed, but because we understand how it is regulated, we can basically design or regulate a new aging path,” Hao told .

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“Our study raises the possibility of rationally designing gene or chemical-based therapies to reprogram how human cells age, with a goal of effectively delaying human aging and extending human healthspan,” Hao said in a statement.

Scientists said that they plan to test their model in complex cells, organisms, and eventually, humans, as well as testing how combinations of therapeutics and drugs could lead to further longevity.

“Aging is a fundamental biological question. We know very little about the aging process,”

When it comes to medical relevance, , “aging is related to many diseases so if we can help slow aging or promote longevity, it will be beneficial for society.”

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Source : CNN

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Gurucharan Singh of Taarak Mehta Ka Ooltah Chashmah gets hospitalised and releases a video: “Zaada kharab ho gayi hai haalat bohot.” “Troubling News: Gurucharan Singh of Taarak Mehta Ka Ooltah Chashmah Hospitalized, Shares Worrying Update: ‘Zaada Kharab Ho Gayii Hai Haalat Bhoot'”

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2 weeks ago

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January 8, 2025

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Gurucharan Singh of Taarak Mehta Ka Ooltah Chashmah gets hospitalised and releases a video: “Zaada kharab ho gayi hai haalat bohot.” “Troubling News: Gurucharan Singh of Taarak Mehta Ka Ooltah Chashmah Hospitalized, Shares Worrying Update: ‘Zaada Kharab Ho Gayii Hai Haalat Bhoot'”

Gurucharan Singh gave a glimpse of his hospital room and himself. In the clip, he didn’t reveal the reason for getting hospitalised.
Actor Gurucharan Singh, who became famous for playing Roshan Sodhi in Taarak Mehta Ka Ooltah Chashmah, has been hospitalised. Taking to Instagram on Tuesday, Gurucharan shared a video of himself as he rested on the hospital bed.

Taarak Mehta’s Gurucharan Singh hospitalised

In the video, Gurucharan said that he was very unwell. The actor also gave a glimpse of his hospital room. He panned the camera towards his hand on which a cannula was seen. The actor was seen wearing a yellow and blue shirt. He wrapped himself in a shawl.

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What Gurucharan said about his health

The actor started the video by saying, “Haalat bohot zaada kharab ho gayi hai (My condition has gotten worse).” He then wished his fans for Gurpurab. Gurucharan continued, “My blood tests have been done. I will update you about my health soon. Haalat dekho (See my condition).” He, however, didn’t reveal the reason for getting hospitalised.

Sharing the caption, Gurucharan wrote, “DHAN DHAN SAHEB SIRI GURU GOBIND SINGH SAHEB MAHARAJ JI DE GURPURAB DIYA LAKH LAKH CRORE CRORE WADHAIYA Ji (folded hands emojis).

Kal GURPURAB te GURU SAHEB Ji ne mainu nava jeewan Bakshia, GURU SAHEB Ji nu Unlimited Infinite times Dhanvaad (Yesterday on Guru Purab, Guru Sahebji gave me a new lease on life. I thank him infinite times).”

“Ji te App saaria nu jinna de GURU SAHEB ji di Kirpa sadke Ajj aap Ji de saamne zinda haan, sabnu dilo namahkaar te Dhanvaad. Thank you to Everyone. RAB RAKHA G, TE, WAHEGURU G MEHAR KARAN G, WAHEGURU JI KA KHALSA WAHEGURU JI KI FATEH,” he concluded.

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Last year Gurucharan disappeared for weeks

Gurucharan made headlines in 2024 after he went missing in April. He returned to his Delhi home in May and said that he was facing some personal and professional issues, which led him to go on a “spiritual journey.”

In April, Gurucharan’s distressed father filed a complaint with Delhi Police, detailing his son’s sudden disappearance since his departure for Mumbai. According to his father’s statement, Gurucharan, who was visiting his parents in Delhi, was expected to return to Mumbai. But he never reached the city.

During the initial investigation, the police also found that the actor was operating multiple bank accounts for financial transactions and was frequently using credit cards despite not being in a sound fiscal state.

Gurcharan in TMKOC

Gurcharan played Roshan in Taarak Mehta Ka Ooltah Chashmah until 2012, but returned in 2013 due to his fans’ demand. He finally left the show in 2020. Balwinder Singh Suri replaced him. In a heartfelt video, Gurucharan appeared visibly weak and expressed his concerns, saying, “Zaada kharab ho gayi hai haalat bohot,” meaning his condition had deteriorated significantly.

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Gurucharan Singh, best known for his role as Sodhi in the popular TV show Taarak Mehta Ka Ooltah Chashmah, recently shared troubling news with his fans. The actor, who has been a fan favorite for years, was hospitalized due to health complications and took to social media to update his followers on his condition.

In the video, he assured his fans that he was receiving medical attention and thanked them for their support during this difficult time. His words resonated with his audience, who flooded social media with messages of concern and well-wishes for his speedy recovery. Gurucharan’s fans have been expressing their love for the actor, hoping to see him back on his feet soon.

#GurucharanSingh #TaarakMehtaKaOoltahChashmah #Hospitalized #HealthUpdate #ZaadaKharab #GetWellSoon #TMKOC #TVStars #SupportAndPrayers #RecoveryJourney

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