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Scientists may found a way to delay aging

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Scientists may found a way to delay aging

Getting old is inevitable, but scientists at the University of California San Diego (UCSD) may be one step closer to being able to delay the aging process.

A team of scientists studied aging in yeast — chosen because its cells are easily manipulated — to try and understand if different cells age at the same rate, and for the same reason.

What they found was intriguing. Even cells made of the same genetic materials and within the same environment aged in “strikingly distinct ways,” according to the scientists, who published their findings in the journal Science.

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About half of the yeast cells aged because of a gradual decline in the nucleolus, a round body located in the nucleus of a cell, the scientists learned, by using techniques including microfluidics and computer modeling.

However, the other half aged because of a dysfunction of mitochondria, which produce a cell’s energy.

Scientists said that the cells go down one of two paths — nuclear or mitochondrial — early in life, and they continue with the aging route until they ultimately decline and die.

Researchers performed further tests to understand how the cells behaved.

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“To understand how cells make these decisions, we identified the molecular processes underlying each aging route and the connections among them, revealing a molecular circuit that controls cell aging, analogous to electric circuits that control home appliances,” said Nan Hao, senior author of the study and an associate professor in UCSD’s division of biological sciences’ molecular biology section.

After modeling the “aging landscape,” the team of researchers found they could manipulate — and optimize — the process of aging, using computer simulations to reprogram the master circuit and modify its DNA.

They were then able to create a “novel aging route,” with a dramatically extended lifespan. This, researchers believe, could ultimately lead to the possibility of delaying human aging.

“This is an aging path that never existed, but because we understand how it is regulated, we can basically design or regulate a new aging path,” Hao told .

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“Our study raises the possibility of rationally designing gene or chemical-based therapies to reprogram how human cells age, with a goal of effectively delaying human aging and extending human healthspan,” Hao said in a statement.

Scientists said that they plan to test their model in complex cells, organisms, and eventually, humans, as well as testing how combinations of therapeutics and drugs could lead to further longevity.

“Aging is a fundamental biological question. We know very little about the aging process,”

When it comes to medical relevance, , “aging is related to many diseases so if we can help slow aging or promote longevity, it will be beneficial for society.”

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Source : CNN

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DTC to start electric buses from 3 Delhi ISBTs to Noida airport by May end

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DTC to start electric buses from 3 Delhi ISBTs to Noida airport by May end

The buses will start and currently serve Greater Noida and Jewar, even though the airport is probably not going to be operational by May By the end of May, the Delhi Transport Corporation (DTC) plans to begin operating electric buses from the Capital to the soon-to-be Noida International Airport (NIA) in Jewar, according to officials. The buses will begin at.

Delhi’s three Inter State Bus Terminals (ISBTs) — Maharana Pratap ISBT at Kashmere Gate, Swami Vivekanand ISBT at Anand Vihar, and Veer Hakikat Rai ISBT at Sarai Kale Khan — and currently serve Greater Noida and Jewar, even though the airport is probably not going to meet the May deadline to be operational The Delhi Transport Corporation (DTC) is set to launch.

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Electric bus services connecting Delhi’s Inter-State Bus Terminals (ISBTs) to the upcoming Noida International Airport (NIA) in Jewar by the end of May 2025. This initiative aims to enhance connectivity between the national capital and the new airport, providing a March 2025, DTC and NIA signed operate thesesustainable and efficient mode transportation for.

Key Features of the Service

  • Routes and Terminals: The electric buses will operate from three major ISBTs in Delhi: Maharana Pratap ISBT at Kashmere Gate, Swami Vivekanand ISBT at Anand Vihar, and Veer Hakikat Rai ISBT at Sarai Kale Khan. Initially, these buses will serve areas in Greater Noida and Jewar, catering to the March 2025, DTC and NIA signed an MoU to operate these demand for public transport in these regions.
  • Memorandum of Understanding (MoU): In March 2025, DTC and NIA signed an MoU to operate these bus services, formalizing the collaboration between the two entities The fleet will consist of air-conditioned, low-floor electric buses equipped with modern amenities, including GPS tracking, CCTV cameras, panic buttons, and broad aisle spaces to accommodate luggage. These features aim to ensure.
  • Commuters passenger safety and comfort during transit While the exact fare amounts are yet to be finalized, discussions are ongoing in consultation with the Yamuna Expressway Industrial Development Authority (Yeida), which manages the Jewar area. The authorities aim to establish a cost-effective fare structure for commuters The bus services will initially be deployed on a pilot basis. Depending demand.

Additional Considerations

  • Infrastructure Development: A four-kilometer stretch of road that will be part of the bus route is not fully developed yet. DTC has reached out to Yeida to ascertain the usability and development timeline of this segment to ensure seamless operations. and passenger feedback, routes may be adjusted, and the number of buses increased to better serve commuters this, the bus services will begin as scheduled.
  • Airport Operational Timeline: Although the NIA was expected to commence operations by mid-May 2025, it is likely to miss this deadline due to ongoing construction work. Despite this, the bus services will begin as scheduled, providing connectivity to the surrounding areas in the interim providing connectivity to the surrounding areas in the interi This initiative reflects DTC’s commitment to.
  • Enhancing public transportation infrastructure and promoting eco-friendly travel options in the National Capital Region. By introducing electric buses on this route, the corporation aims to offer a reliable and sustainable alternative for commuters traveling between Delhi and the upcoming Noida International The Delhi Transport Corporation (DTC) is set to commence electric bus services.
  • connecting Delhi’s Inter-State Bus Terminals (ISBTs) to the upcoming Noida International Airport (NIA) in Jewar by the end of May 2025. This initiative aims to provide eco-friendly and convenient transportation options for commuters traveling between Delhi and the new airport NIA was expected to commence.
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