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Ailments in covid-19 trials raise questions about vaccine method

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5 years ago

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Ailments in covid-19 trials raise questions about vaccine method

Two Covid-19 vaccines stalled by potential side effects have one key feature in common: Both are based on adenoviruses, cold germs that researchers have used in experimental therapies for decades with varying results.
Johnson & Johnson said late Monday it would pause its trial to investigate an illness, which it didn’t specify, in a study participant. Meanwhile, AstraZeneca Plc’s U.S. trial of the vaccine it’s developing with the University of Oxford has been halted by regulators for more than a month after neurological symptoms arose in two volunteers.
With AstraZeneca in a pit stop, vaccines from Moderna Inc. and the Pfizer Inc.-BioNTech SE partnership have taken the lead in the race to be first out with a shot. Meanwhile, the two paused trials are reviving questions about adenoviral vectors, which have been used in laboratory, animal and human experiments for years. In some cases, the experiments have succeeded, but not always.
And this year, with Covid-19 vaccines entering strongly into the politics of the hour, transparency and trust are key to fighting a virus that’s hit more than 39 million people globally and hamstrung economies. If concerns about side effects in experimental vaccines in trials using adenoviruses are validated, it could boost skepticism in the general public and raise questions for other drugmakers.
“While it could be a coincidence,” said Sam Fazeli, a Bloomberg Intelligence analyst, in a research note, “there’s still the possibility that adenoviral vector vaccines run a higher risk of rare side effects – such as autoimmune attacks like transverse myelitis – than those of Pfizer-BioNTech, Moderna or Novavax.”
Pauses to investigate side effects aren’t unusual in vaccine trials, which require a high safety bar because they’re taken by healthy people. Oxford has said there’s insufficient evidence to connect the participants’ illnesses to their vaccine. Its human tests in the U.K., South Africa and Brazil resumed weeks ago.
Adenoviral vectors are well studied, versatile, and shown to be well tolerated, making them good candidates for Covid vaccines, AstraZeneca said in an email. Reactions to the Astra/Oxford vaccine in early studies were comparable to those seen in previous trials of other vaccines using adenoviruses, the company said. Oxford researchers declined to comment.
If adenoviruses are associated with the side effects that have appeared in Covid vaccines, it may set back development of numerous projects, as it did with HIV and gene therapy. There are more than a dozen Covid vaccines in development based on adenoviruses, according to the World Health Organization.
Should investigators in the current trials determine the cause of the episodes is related to the vaccines, they would look for potential links to the adenovirus approach as well as to the spike protein the vaccine is designed to make to prepare the immune system for a real infection, according to Washington University’s Kinch.
At this point, he said, there’s not enough information to know. “Is this just random chance?” Kinch said. “First and foremost, there’s bad luck. If it turns out there’s a correlation and a causation, then the conversation very quickly turns.”

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Bollywood

Siddharth Malhotra carries pregnant wife Kiara Advani’s bag in unseen pic from New York ahead of Met Gala 2025

Published

23 hours ago

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May 6, 2025

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Siddharth Malhotra carries pregnant wife Kiara Advani’s bag in unseen pic from New York ahead of Met Gala 2025

One of Bollywood actor Kiara Advani’s most exciting and memorable years will be 2025. Kiara and her famous husband, Sidharth Malhotra, revealed their first child’s impending arrival in February of this year. The couple and soon-to-be parents were seen outside a hospital two weeks ago, and Kiara was the first to show off her gorgeous baby bulge and pregnancy glow.

To top it all off, Kiara will soon be attending her first Met Gala! She and Siddharth were photographed outside their New York hotel only last night. A fan posted this photo of Kiara Advani and Siddharth Malhotra on social media when they arrived at their New York hotel. Now, it has In a heartwarming display of affection, Bollywood actor Sidharth Malhotra.

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Recently spotted in New York City carrying his pregnant wife Kiara Advani’s handbag, ahead of her much-anticipated Met Gala 2025 debut. The candid moment, captured outside their hotel, quickly went viral on social media, with fans praising Siddharth’s supportive gesture

Kiara, expecting her first child with Siddharth, looked radiant in an oversized jacket layered over a midi dress, subtly showcasing her baby bump. Siddharth, dressed casually in a button-down shirt, followed closely behind, holding her white handbag—a simple yet touching act that resonated with fans online. The photo, shared on Reddit, garnered comments like.

The couple, who tied the knot in February 2023, announced their pregnancy earlier this year. Kiara’s appearance at the Met Gala marks a significant milestone, as she prepares to walk the red carpet in a custom Gaurav Gupta ensemble. While it’s yet to be confirmed if Siddharth will accompany her on the red carpet, his presence in New York underscores his unwavering.

Fans eagerly await Kiara’s Met Gala debut, anticipating a blend of Bollywood glamour and appearance at the Met Gala marks a significant milestone to walk the red He’s holding her bag they’re so highlighting the couple’s endearing dynamic international fashion flair. With Siddharth by her side, the couple continues to capture hearts, embodying love and partnership both on and off the screen support during this special time.

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In a heartwarming moment captured in New York City, Bollywood actor Siddharth Malhotra was seen carrying his pregnant wife Kiara Advani’s handbag as they entered their hotel ahead of the Met Gala 2025. The candid photograph, shared by a fan on Reddit, quickly went viral, with fans praising Siddharth’s supportive gesture Kiara, expecting her first child Siddharth.

Looked radiant in an oversized jacket layered over a midi dress, subtly showcasing her baby bump. Siddharth, dressed casually in a button-down shirt, followed closely behind, holding her white handbag—a simple yet touching act that resonated with fans online The couple, who tied the knot in February 2023, announced their pregnancy earlier this year. Kiara’s appearanc.

At the Met Gala marks a significant milestone, as she prepares to walk the red carpet in a custom Gaurav Gupta ensemble. While it’s yet to be confirmed if Siddharth will accompany her on the red carpet, his presence in New York underscores his unwavering support during this special time Fans eagerly await Kiara’s Met Gala debut, anticipating a blend of Bollywood.

Glamour and international fashion flair. With Siddharth by her side, the couple continues to capture hearts, embodying love and partnership both on and off the screen Kiara, expecting her first child with, looked radiant in an oversized jacket layered over a midi dress, subtly showcasing her baby bump. , dressed casually in a button-down shirt, followed Kiara’s carpet in a custom Gaurav Gupta ensemble.

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