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In a first in India, Pompe patient gives birth to healthy baby

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In a first in India, Pompe patient gives birth to healthy baby

A 24-year-old Kerala woman with the rare and fatal genetic disease ‘Pompe’ gave birth to a healthy baby in a private hospital in Kochi last week. The incident has raised high hopes for the medical fraternity that the case is a testimony that people diagnosed with the grave disease can lead a normal life if it is diagnosed and treated early.

According to doctors attending to the patient, who hails from Kollam, both the mother and baby are doing well.

Pompe disease, a Lysosomal Storage Disorder (LSD), is a serious chronic, debilitating condition, caused by pathogenic abnormalities or mutations in the GAA gene.

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Patients with this rare condition have muscle weakness to a spectrum of severe complications, and often require long term, specialized treatments and management through Enzyme Replacement Therapy (ERT), a hospital statement said here on Wednesday.

Dr Sheela Nampoothiri, Head of Paediatric Genetics of Amrita Hospital said this is the first recorded case of a Pompe patient in India who underwent the entire cycle of pregnancy to deliver a healthy baby.

This case is a testimony that patients diagnosed with rare diseases like Pompe can lead a near-normal life if they are put on life-saving treatment early, Namboothiri said. According to the statement, she expressed happiness that the baby, who weighed 2.8 kg at birth, does not carry the defective gene and is free of Pompe disease.

According to Manoj Manghat, Kerala state co-ordinator of Lysosomal Storage Disorders Support Society, hopes have now been raised within the rare disease community, not just in Kerala, but across the country that patients who are put on treatment at an appropriate time can lead a normal life like others. Society is a patient advocacy group set up to fight the cause of rare disease patients in the country.

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Also Read : “TIME HAS COME TO ACCEPT THAT TALKS WITH CHINA WON’T HELP”: US NATIONAL SECURITY ADVISER ON LADAKH

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Excess belly fat is your 40s? Study explains why it happens

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Excess belly fat is your 40s? Study explains why it happens

A study led by City of Hope Medical Center and UCLA has found that a certain type of fat cell in the middle age is responsible for fat accumulation in the belly area. This development challenges the conventional notion about middle-age weight gain. The study, which was conducted in India, revealed that a new type of fat cell is responsible for fat accumulation.

The belly area. The findings suggest that the mid-life belly may not be due to diet or the absence of regular workout, but rather a new type of fat cell that develops in middle age. The study also highlighted the Festival of Crickit Quiz and photos from the century of leadership. The study also highlighted the upcoming release of Rajamouli Prabhas’ Baahubali theatres.

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A study by researchers from the City of Hope Medical Center and UCLA found that the human body starts rapidly making fat around their 40s, in the deep belly area. The researchers tracked fat formation in mice of different ages, finding that mice of 12 months (equivalent to 40 years in humans) demonstrated sudden fat formation in the belly area. They also observed similar.

Patterns in mice that are observed in humans in middle age – expanded waistlines, reduced energy expenditure, and insulin resistance. These changes indicate metabolic differences that can increase the risk of diabetes and heart diseases. The researchers identified a new fat cell precursor called “CP-A” (committed preadipocyte, age-enriched), which appeared middle age.

Rapidly developed into mature fat cells. They also examined the fat tissue of humans and observed the same CP-A cells in middle-aged humans. The research team from City of Hope Medical Center and UCLA concluded that despite the low turnover rate of adipocytes in young adults, adipogenesis is unlocked during middle age, explaining why the human body starts.

Why Belly Fat Increases in Your 40s

  1. Slower Metabolism: As you age, your body’s metabolism tends to slow down. This means you burn fewer calories at rest, making it easier to gain weight if dietary habits and physical activity levels remain unchanged. This slowdown can lead to a gradual increase in body fat over time. ​
  2. Hormonal Changes: In women, the transition to menopause brings a decrease in estrogen levels, which can lead to fat being redistributed to the abdominal area. In men, a decline in testosterone levels can result in increased fat accumulation around the belly. ​
  3. Loss of Muscle Mass: Aging is associated with a gradual loss of muscle mass, known as sarcopenia. Since muscle tissue burns more calories than fat tissue, a decrease in muscle mass can lead to a slower metabolism and increased fat accumulation. ​
  4. Lifestyle Factors: Sedentary behavior, poor dietary choices, high stress levels, and inadequate sleep can contribute to weight gain and the accumulation of belly fat. These factors can disrupt hormonal balance and increase cravings for unhealthy foods

Health Implications

Excess abdominal fat, particularly visceral fat that surrounds internal organs, is associated AS with an increased risk of developing chronic conditions such as heart disease, type 2 diabetes, and certain cancers. ​

  • Regular Exercise: Engage in a combination of aerobic exercises (like walking, cycling, or swimming) and strength training to build muscle mass and boost metabolism.​
  • Balanced Diet: Focus on a diet rich in whole foods, including fruits, vegetables, lean proteins, and whole grains. Limit intake of processed foods, sugary beverages, and excessive alcohol.​

By understanding the factors contributing to belly fat in your 40s and adopting a proactive approach, you can manage your weight and maintain overall health Rapidly making fat.

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