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Protein partners have been found by researchers who may help to mend cardiac muscle.

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Protein partners have been found by researchers who may help to mend cardiac muscle.

The work is being carried out by researchers at the UNC School of Medicine, and could have a substantial impact on the development of future treatments for broken hearts.  Researchers have found a way to reprogram scar tissue cells (fibroblasts) to become healthy heart muscle cells. The study was published in the journal Cell Stem Cell (cardiomyocytes) Researchers are looking into possibly treating or one day curing cardiac disease.

They used a gene activity-controlling protein called Ascl1, which is well recognised to be an essential protein for converting fibroblasts into neurons. Researchers hope to use this technique to give patients injections to transform harmful cells into helpful ones. Fibroblast over-activity underlies many major diseases and conditions including heart failure, chronic obstructive pulmonary disease, liver disease, kidney disease and the scar-like brain damage that occurs after a stroke. “Reprogramming fibroblasts has long been one of the important goals in the field of stem cell therapy,” Qian says. A team of researchers led by Professor Yingying Qian has developed a way to reprogram mice fibroblasts into cardiomyocytes, liver cells, and neurons. Qian’s team studied the variations in gene activity patterns and variables that control gene activity during these three separate reprogrammings. A team of researchers has discovered that converting fibroblasts into neurons activated genes related to cardiomyocytes. Ascl1, one of the master-programmer “transcription factor” proteins, was the cause of this activation. They were shocked to see that it significantly increased reprogramming efficiency by more than ten times.

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Gurucharan Singh of Taarak Mehta Ka Ooltah Chashmah gets hospitalised and releases a video: “Zaada kharab ho gayi hai haalat bohot.” “Troubling News: Gurucharan Singh of Taarak Mehta Ka Ooltah Chashmah Hospitalized, Shares Worrying Update: ‘Zaada Kharab Ho Gayii Hai Haalat Bhoot'”

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Gurucharan Singh of Taarak Mehta Ka Ooltah Chashmah gets hospitalised and releases a video: “Zaada kharab ho gayi hai haalat bohot.” “Troubling News: Gurucharan Singh of Taarak Mehta Ka Ooltah Chashmah Hospitalized, Shares Worrying Update: ‘Zaada Kharab Ho Gayii Hai Haalat Bhoot'”

Gurucharan Singh gave a glimpse of his hospital room and himself. In the clip, he didn’t reveal the reason for getting hospitalised.
Actor Gurucharan Singh, who became famous for playing Roshan Sodhi in Taarak Mehta Ka Ooltah Chashmah, has been hospitalised. Taking to Instagram on Tuesday, Gurucharan shared a video of himself as he rested on the hospital bed.

Taarak Mehta’s Gurucharan Singh hospitalised

In the video, Gurucharan said that he was very unwell. The actor also gave a glimpse of his hospital room. He panned the camera towards his hand on which a cannula was seen. The actor was seen wearing a yellow and blue shirt. He wrapped himself in a shawl.

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What Gurucharan said about his health

The actor started the video by saying, “Haalat bohot zaada kharab ho gayi hai (My condition has gotten worse).” He then wished his fans for Gurpurab. Gurucharan continued, “My blood tests have been done. I will update you about my health soon. Haalat dekho (See my condition).” He, however, didn’t reveal the reason for getting hospitalised.

Sharing the caption, Gurucharan wrote, “DHAN DHAN SAHEB SIRI GURU GOBIND SINGH SAHEB MAHARAJ JI DE GURPURAB DIYA LAKH LAKH CRORE CRORE WADHAIYA Ji (folded hands emojis).

Kal GURPURAB te GURU SAHEB Ji ne mainu nava jeewan Bakshia, GURU SAHEB Ji nu Unlimited Infinite times Dhanvaad (Yesterday on Guru Purab, Guru Sahebji gave me a new lease on life. I thank him infinite times).”

“Ji te App saaria nu jinna de GURU SAHEB ji di Kirpa sadke Ajj aap Ji de saamne zinda haan, sabnu dilo namahkaar te Dhanvaad. Thank you to Everyone. RAB RAKHA G, TE, WAHEGURU G MEHAR KARAN G, WAHEGURU JI KA KHALSA WAHEGURU JI KI FATEH,” he concluded.

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Last year Gurucharan disappeared for weeks

Gurucharan made headlines in 2024 after he went missing in April. He returned to his Delhi home in May and said that he was facing some personal and professional issues, which led him to go on a “spiritual journey.”

In April, Gurucharan’s distressed father filed a complaint with Delhi Police, detailing his son’s sudden disappearance since his departure for Mumbai. According to his father’s statement, Gurucharan, who was visiting his parents in Delhi, was expected to return to Mumbai. But he never reached the city.

During the initial investigation, the police also found that the actor was operating multiple bank accounts for financial transactions and was frequently using credit cards despite not being in a sound fiscal state.

Gurcharan in TMKOC

Gurcharan played Roshan in Taarak Mehta Ka Ooltah Chashmah until 2012, but returned in 2013 due to his fans’ demand. He finally left the show in 2020. Balwinder Singh Suri replaced him. In a heartfelt video, Gurucharan appeared visibly weak and expressed his concerns, saying, “Zaada kharab ho gayi hai haalat bohot,” meaning his condition had deteriorated significantly.

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Gurucharan Singh, best known for his role as Sodhi in the popular TV show Taarak Mehta Ka Ooltah Chashmah, recently shared troubling news with his fans. The actor, who has been a fan favorite for years, was hospitalized due to health complications and took to social media to update his followers on his condition.

In the video, he assured his fans that he was receiving medical attention and thanked them for their support during this difficult time. His words resonated with his audience, who flooded social media with messages of concern and well-wishes for his speedy recovery. Gurucharan’s fans have been expressing their love for the actor, hoping to see him back on his feet soon.

#GurucharanSingh #TaarakMehtaKaOoltahChashmah #Hospitalized #HealthUpdate #ZaadaKharab #GetWellSoon #TMKOC #TVStars #SupportAndPrayers #RecoveryJourney

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