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PTSD risk is linked to certain brain responses to stressful stress

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PTSD risk is linked to certain brain responses to stressful stress

According to the largest prospective study of its kind, people who were exposed to potentially dangerous scenarios and who had lower hippocampal activity had more severe posttraumatic stress disorder (PTSD) symptoms in the days and weeks that followed the event.

This relationship between decreased hippocampal activity and the chance of developing PTSD was especially apparent in people who had more defensive reflexive reflexes to being startled.

According to this study, which was published in the journal Neurosci, those who react more defensively to potentially dangerous occurrences may find it more difficult to determine whether an event is risky or not. They are also more likely to experience severe forms of PTSD, which include symptoms like being constantly alert for danger, engaging in self-destructive behaviour like binge drinking or speeding, having trouble falling asleep and staying awake, being irritable, having angry outbursts, and having nightmares.

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According to senior author Vishnu Murty, PhD, assistant professor of psychology and neuroscience at Temple University, “these findings are important both to identify specific brain responses associated with vulnerability to develop PTSD, and to identify potential treatments focused on memory processes for these individuals to prevent or treat PTSD.”

The national Advancing Understanding of Recovery after Trauma (AURORA) Study, a collaboration between multiple institutions, is financed by the National Institutes of Health, charitable foundations like One Mind, and partnerships with top technology firms. Samuel McLean, MD, MPH, head of the UNC Institute for Trauma Recovery and professor of psychiatry and emergency medicine at the University of North Carolina School of Medicine, serves as the organising primary investigator.

Researchers can use data from patient participants who visit emergency rooms at hospitals around the nation after suffering trauma from vehicle accidents or other traumatic situations thanks to AURORA. AURORA’s main objective is to promote the creation and evaluation of preventive and therapeutic interventions for people who have endured traumatic situations.

Only a small percentage of trauma survivors get PTSD, which is linked to greater sensitivity to danger and a reduced capacity to activate neuronal pathways that retrieve emotional memories, according to AURORA scientists. However, it is unclear how these two processes interact to raise the chance of getting PTSD. Murty and colleagues studied the brain and behavioural reactions of people two weeks after trauma to better understand these processes.

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Researchers discovered that the individuals with the most defensive reactions to startling events following trauma had the least activity in their hippocampus and the least activity in their hippocampus, along with laboratory and survey-based assessments for trauma.

According to Busra Tanriverdi, the study’s principal researcher and a doctoral student at Temple University, “among these people, increased defensive reactions to dangers may bias them against learning information about what is happening so that they can determine what is safe and what is harmful.” These findings point to a crucial PTSD biomarker that is concerned with how survivors of trauma create and recall memories.

According to McLean, an author on the publication, “these most recent findings add to our list of AURORA discoveries that are aiding us in understanding the differences between people who go on to acquire posttraumatic stress disorder and those who do not.” Studies that concentrate on the immediate aftermath of trauma are crucial because they help us better understand how PTSD manifests itself and how to prevent and cure it.

According to Brandon Staglin, president of One Mind, “Since beginning our financial support of the AURORA Study in 2016, we remain steadfast in our commitment to helping AURORA investigators make significant discoveries and to bridge the gaps that exist in mental health research funding and patient support.”

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Kunal Kemmu Reveals Crucial, Heartbreaking Struggle of Being Jobless

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Kunal Kemmu Reveals Crucial, Heartbreaking Struggle of Being Jobless

The glamour and glamour of Bollywood can mislead us to the hard, cold reality that lies behind the velvet curtains. We see the flashing cameras, beautiful attire, and thunderous ovation, but we rarely see a gifted artist’s quiet anguish as he waits for the phone call.

Recently, the immensely adaptable Kunal Kemmu shattered this shiny façade by revealing a terribly difficult period in his career. Despite his established acting talent and irresistible charm, the actor disclosed a heartbreaking truth that many in the creative business covertly face.

He openly discussed being unemployed for six months to a year. This devastating revelation serves as a sharp reminder that in the entertainment industry, success is dangerously transitory and rejection is an ever-present shadow.

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The Toxic Illusion of Industry Advice

When a picture fails to do well at the box office, the implications for an actor can be swift and severe. Kunal Kemmu described how a single project’s failure entirely halted his momentum, severing a blossoming career and leaving him stuck at home.

During this dark and alienating era, well-meaning strangers and business insiders raced to offer him advice. However, the nature of this advise emphasises the superficial, performance mentality that pervades the entertainment industry.

Instead of being told to improve his skills or patiently wait for a story that matched his talent, he was subjected to odd societal demands. People sincerely recommended him to hire aggressive public relations personnel, hold lavish parties, network tirelessly, and give expensive presents to key persons in order to remain relevant.


Rejecting the Performative Circus

For an actor who has always prioritised depth above theatrics, this trite counsel felt completely out of place. Kunal Kemmu said that, while such transactional approaches may work for some people, they do not accord with his underlying principles.

The strain to play an off-camera role can be just as stressful as presenting a complex character on stage. Kunal chose not to participate in the superficial lifestyle of mailing gifts or throwing fictitious gatherings only to get a film role.

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Instead of feeding a frantic public relations narrative, he chose to maintain his personal dignity while emphasising his artistic ability. This modest disregard of industry standards demonstrates the enormous mental strength required to endure the unpredictable nature of Indian cinema.


The psychological toll of being creative while unemployed is a significant problem that few celebrities openly mention. Kunal Kemmu did not hold back while recounting the extreme uneasiness and paralysing worry that overwhelmed him throughout his year-long forced leave.

When you are entirely out of employment, a corrosive loop of self-doubt will inevitably take over your head. The actor admitted to continually worrying if he’d ever get the opportunity to appear in front of a camera again.

This great vulnerability reveals a universal reality about the performing profession. Whether you are a famous superstar or a struggling newbie, the frightening unpredictability of the entertainment industry spares no one.

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The Actor’s Ultimate Dilemma

Aside from the emotional discomfort, a protracted lack of work throws an artist into a corner, posing a significant ethical quandary. Actors are constantly torn between waiting for high-quality scripts and accepting substandard assignments solely for financial survival.

Kunal Kemmu acknowledged the agonising struggle that most creative professionals undergo at certain stages in their careers. The fear of being forgotten by the public drives many artists to make significant compromises to their artistic integrity.

It takes a lot of patience and self-belief to say no to subpar job when your calendar is empty. Kunal’s tale demonstrates that following your intuition can be extremely painful but eventually beneficial.


Embracing the Ever-Changing Acts of Life

Today, Kunal Kemmu is experiencing a stunning professional renaissance, juggling acting commitments, hosting a major reality program, and celebrating directing success. Nonetheless, he remains delightfully grounded, acutely aware that the current spotlight is not certain to last forever.
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He sees his career as a long film that unfolds brilliantly through distinct acts, rather than a constant apex. This realistic viewpoint enables him to enjoy his current hectic schedule without getting arrogant or complacent.
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Kunal has brought consolation to other artists who are going through their own silent challenges by revealing his difficult period of unemployment. His narrative demonstrates that genuine genius does not require transactional gifts or contrived parties to achieve its proper position in the light.


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