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Combinations of medications may aid in reducing the progression of diabetic kidney damage

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Combinations of medications may aid in reducing the progression of diabetic kidney damage

Combining SGLT2 inhibitors — a newer class of diabetes treatments that reduces blood sugar — with older diabetes meds may help to halt the onset of diabetic kidney impairment, according to a mouse study led by Washington University School of Medicine in St. Louis. Dapagliflozin (Farxiga), empagliflozin (Jardiance), and canagliflozin (Canagliflozin) are some of the most commonly prescribed SGLT2 inhibitors (Invokana).

Kidney disease is the largest cause of death in the United States, impacting 37 million people, many of whom are unaware that their kidneys are failing. There is no cure, and the only therapies for end-stage renal disease are dialysis and kidney transplantation.

A mouse study headed by Washington University School of Medicine in St. Louis reveals that combining SGLT2 inhibitors — a newer class of diabetes treatments that reduces blood sugar — with older diabetes drugs may help to halt the course of diabetic kidney impairment.

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Dapagliflozin (Farxiga), empagliflozin (Jardiance), and canagliflozin (Canagliflozin) are some of the most commonly prescribed SGLT2 inhibitors (Invokana). Janssen Pharmaceuticals, whose experts cooperated on this study, produces the latter.

Diabetic kidney disease affects roughly 40% of type 2 diabetes patients, resulting in renal failure, cardiovascular disease, and early death. Diabetes, renal disease, and kidney failure are more common in African Americans, Native Americans, and Hispanics than in Caucasians.

Diabetes harms the kidneys by preventing them from filtering waste and extra fluids from the body adequately. Most people don’t recognise they have kidney disease until irreversible organ damage occurs since symptoms including nausea, vomiting, sleep difficulties, and swelling limbs are common and nonspecific.

SGLT2 inhibitors, also known as sodium-glucose cotransporter-2 inhibitors, cause the kidneys to excrete excess sugar from the blood, which is then excreted through urine. Humphreys, who is also the Joseph Friedman Professor of Renal Diseases in Medicine, added, “This family of medications is also very protective for heart disease.”

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Although most patients with type 2 diabetes are prescribed only one medicine, the findings of this study show that combination therapy may be more successful since different drug classes target different cell types in the kidney.

The researchers examined how mouse kidneys respond to five diabetes therapy regimens administered to people using mice that had developed diabetic kidney damage. The researchers used single-cell RNA sequencing to look for alterations in the kidneys at the cellular and molecular level as a result of the various therapies. Researchers can use this knowledge to better target certain cells in order to improve medication therapy.

They focused on the impact of three kinds of drugs: SGLT2 inhibitors, angiotensin converting enzyme inhibitors (ACE inhibitors), such as Lisinopril, and Thiazolidinediones (TZD, also known as insulin sensitizers). A common TZD is rosiglitazone.

The study’s first author, Haojia Wu, PhD, an assistant professor in the Division of Nephrology, said, “We structured this study to try to understand how combination medicines affect the kidney differently than single therapies.” “We discovered that each of the distinct classes of medications targeted different cell types, offering a biological justification for combination therapy to help diabetic kidney disease advance more slowly.”

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The study discovered that combining SGLT2 inhibitors with Lisinopril showed superior kidney protection than either of the standalone treatments.

SGLT2 inhibitors also appeared to mislead the kidney into initiating a starvation response, similar to how the body slows down its metabolism while fasting for long periods of time, according to the researchers.

This could lower the kidney’s overall energy consumption, allowing it to perform more efficiently and putting less strain on it in the long run, which could explain why this family of medications is so effective,” Humphreys added.

“Treatments for diabetic kidney disease are at an all-time high,” he noted. “Our research adds to the growing body of data that combining medicines has significant benefits for patients.” Such techniques, we believe, should be used in ordinary clinical practise.”

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Future observational studies in persons using combo medicines, according to Humphreys, should provide more data.

 

 

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Thug Life Movie Review & Release Live Updates: Kamal Haasan’s Bold New Venture – Is it the Hit We Expected?

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Thug Life Movie Review & Release Live Updates: Kamal Haasan’s Bold New Venture – Is it the Hit We Expected?

Kamal Haasan’s Bold New Venture

Kamal Haasan, the versatile legend of Indian cinema, is back on the big screen with his latest thriller, Thug Life. After weeks of anticipation and a gripping promotional campaign, fans have eagerly awaited the release of this high-octane action drama. The movie, directed by debutant director Arvind Rao, promises to showcase Haasan in a never-before-seen avatar, leading to sky-high expectations. So, does Thug Life live up to the hype? In this blog, we bring you an in-depth review of the film, along with live updates from the first-day box office response. Is Thug Life the next blockbuster hit Kamal Haasan fans have been waiting for?

A Thrilling First Look: What’s Thug Life All About?
At its core, Thug Life is an action-packed thriller that explores the lives of notorious criminals, their complex relationships with law enforcement, and the grey areas of morality. Kamal Haasan plays Vikram Singh, a larger-than-life anti-hero with a troubled past who finds himself caught between the law and the underworld. The film also stars an ensemble cast, including the brilliant actress Simran, who plays a key role as Vikram’s moral compass.

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From the first teaser, it’s clear that Thug Life is set against the backdrop of a gritty urban world, filled with explosive action sequences, intense drama, and gripping twists. The film promises to delve deep into themes of justice, vengeance, and personal redemption. Kamal’s performance, combined with the intriguing premise, has set the stage for a grand theatrical release.

Plot and Direction: The Power of Storytelling
Thug Life is crafted in a fast-paced manner, with suspense building at every corner. The screenplay is written in a way that constantly keeps the audience on edge, making them question the true intentions of the characters. The film’s direction by Arvind Rao has been appreciated for its bold approach in showcasing complex characters and real-world dilemmas.

Kamal Haasan, known for his ability to transform into any character, does not disappoint here. He brings his unparalleled experience to the table, portraying a character who walks the thin line between good and evil. His performance is undoubtedly one of the highlights of the film.

Simran’s portrayal of Maya, a fierce and intelligent woman who challenges Vikram’s decisions, complements Haasan’s character beautifully. Their chemistry on screen elevates the emotional stakes, making the action sequences more impactful.

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Is the Action Worth the Hype?
The action sequences in Thug Life are nothing short of spectacular. From high-speed chases to hand-to-hand combat, the film delivers thrills on every front. The choreography, especially in the fight scenes, stands out for its fluidity and precision. Kamal Haasan, known for his commitment to physical transformation, performs many of the stunts himself, showcasing his dedication to the craft.

One of the standout moments is a tense sequence set in an abandoned warehouse where Vikram faces off against a group of armed criminals. The scene is intense, and the cinematography captures the chaos and confusion, making it a thrilling experience.

Music & Sound Design: A Powerful Impact
The film’s music, composed by the talented Anirudh Ravichander, perfectly complements the high-octane action and dramatic moments. Tracks like “Thug Life Anthem” and “Vikram’s Vengeance” have already started to trend on music platforms, and it’s easy to see why. The music amplifies the tension and excitement, enhancing the overall cinematic experience.

The sound design deserves special mention. Whether it’s the ominous hum during a quiet moment or the deafening roar during action sequences, the sound elevates the tension and immerses the audience in the world of Thug Life.

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Live Box Office Updates: A Promising Start
As the clock strikes midnight, audiences flock to theaters for the first showings of Thug Life. Early reviews on social media are buzzing with excitement, praising Kamal Haasan’s return to form and the gripping narrative. The film’s powerful action sequences and engaging storyline seem to have hit the right chord with fans.

Box office analysts predict a solid opening for Thug Life. With strong pre-release bookings, particularly in Chennai, Mumbai, and Bengaluru, the film is set for a roaring start. Kamal Haasan’s massive fan base is ensuring long lines at theaters, with advance bookings already sold out in several locations.

Reports from the first-day collections are already rolling in, and the numbers look promising. It’s expected that Thug Life will gross over ₹15 crore on its opening day, making it one of the highest openings for Kamal Haasan in recent years.

The Verdict: Is Thug Life Impressive?
Without a doubt, Thug Life is a powerful cinematic experience that showcases Kamal Haasan in peak form. The film succeeds in offering a gripping storyline, memorable characters, and a stellar performance from its lead. The action sequences and emotional depth set it apart from typical masala entertainers, and its themes resonate with today’s audience.

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While the plot may feel familiar to those who have watched similar thrillers, Thug Life distinguishes itself with its sharp direction, compelling performances, and high-quality production values. If you’re a fan of action films with emotional depth, this is a movie you won’t want to miss.

Rating: 4/5 – A must-watch for Kamal Haasan fans and action movie lovers alike.

Live Updates: Is Thug Life Making Waves?
10:00 AM – First Show Starts:
The first show has begun! Fans are already praising Kamal Haasan’s power-packed performance. Social media is flooded with reactions as people seem impressed with the intense action sequences.

12:30 PM – Early Box Office Numbers:
Thug Life is seeing a great response at the box office. Early reports show packed theaters in Chennai, Hyderabad, and Bengaluru. Looks like Kamal Haasan is in for a hit!

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3:00 PM – Social Media Buzz:
The film’s action and Kamal Haasan’s performance are trending on Twitter and Instagram. Fans are calling it his best role in years. Many are also impressed with the music by Anirudh.

6:00 PM – Fan Reactions:
The film continues to dominate social media as fans share videos from theaters. There’s a lot of love for the film’s emotional depth, making it clear that Thug Life is a crowd favorite.

Final Thoughts:
With such a fantastic opening, Thug Life looks set to make waves at the box office. Kamal Haasan’s stellar performance and the film’s impressive direction ensure that this thriller is more than just a typical action flick – it’s a cinematic experience.

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