Covid -19
New potential treatment for Covid-19 identified by researchers
In a recent study, researchers discovered a potential new treatment that can inhibit the replication of SARS-CoV-2 (the virus that causes Covid-19). In order to reproduce, all viruses, including coronaviruses, infect cells and reprogram them to produce new viruses. The study of “targeting the pentose phosphate pathway for SARS-CoV-2 treatment” has been published by the scientific journal Metabolite.
Studies have shown that cells infected with SARS-CoV-2 can only produce new coronaviruses when their metabolic pentose phosphate pathway is activated. When using the inhibitor of this pathway, benzalkonium thiamine, the replication of SARS-CoV-2 is inhibited, and the infected cells will not produce coronavirus. Research by the School of Biological Sciences at the University of Kent and the Institute of Medical Virology at Goethe University in Frankfurt found that the drug also increases the antiviral activity of “2-deoxy-D-glucose”; a drug that alters host cell metabolism to reduce virus reproduction.
This indicates that pentose phosphate pathway inhibitors such as benzalkonium thiamine are potential new treatment options for Covid-19, whether used alone or in combination with other treatments. In addition, the antiviral mechanism of Benfooxythiamin is different from other Covid-19 drugs such as remdesivir and molnupiravir. Therefore, these resistant viruses may be sensitive to phenoxythiamine.
Professor Martin Michaelis of the University of Kent said: “This is a breakthrough in Covid-19 treatment research. Since the development of drug resistance is a big problem in the treatment of viral diseases, the use of different target therapies is very important and provides further hope for Covid-19 develops the most effective treatment.” “Targeting virus-induced host cell metabolic changes is an attractive way to specifically interfere with the virus replication process,” added Professor Jindrich Cinatl from Goethe University Frankfurt.
News Source : Hindustan Times
Covid -19
Covid infection linked to more type 1 diabetes in kids and teens: Study
Two studies that did not definitively resolve the question of whether the coronavirus can cause the chronic disease of diabetes found that Covid-19 in children and adolescents appeared to increase the chance of acquiring diabetes. Over two years after the pandemic’s commencement, researchers from the Norwegian Institute of Public Health looked at new type 1 diabetes diagnoses using national health registries. They discovered that type 1 diabetes was roughly 60% more likely to develop in children who had tested positive for the coronavirus.
The risk within 30 days of a Covid infection confirmed by a PCR test was examined by the researchers. Young adults were also included in a Scottish study that was presented at the European Link for the Study of Diabetes meeting. This study indicated an increased risk one month following the viral sickness, but the researchers said they discovered no association after that point.
The authors of both studies emphasised that their findings do not necessarily imply a causal link between diabetes and the coronavirus. Other potential causes were emphasised, such as delays in seeking medical attention during the epidemic, the introduction of other diseases, and alterations in way of life brought on by lockdowns.
Jamie Hartmann-Boyce, an associate professor at the Nuffield department of primary care health sciences at the University of Oxford, stated: “There are a lot of plausible reasons that Covid-19 might lead to development of type 1 diabetes, but this remains in no way proved.”
According to a paper earlier this week in the medical journal The Lancet, the number of people with type 1 diabetes, in which the pancreas fails to generate the hormone insulin, may increase from 8.4 million to 17.4 million by the year 2040.
The illness, which has no known treatment and is most frequently diagnosed in children, is thought to be caused by a combination of genetics and exposure to particular pathogens, including SARS-Cov-2 as well as a larger family of viruses known as enteroviruses. Type 2 diabetes, which is more prevalent, typically appears later in life as sedentary habits and weight increase mess with the body’s ability to manage sugar.
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