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New potential treatment for Covid-19 identified by researchers

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New potential treatment for Covid-19 identified by researchers

In a recent study, researchers discovered a potential new treatment that can inhibit the replication of SARS-CoV-2 (the virus that causes Covid-19). In order to reproduce, all viruses, including coronaviruses, infect cells and reprogram them to produce new viruses. The study of “targeting the pentose phosphate pathway for SARS-CoV-2 treatment” has been published by the scientific journal Metabolite.

Studies have shown that cells infected with SARS-CoV-2 can only produce new coronaviruses when their metabolic pentose phosphate pathway is activated. When using the inhibitor of this pathway, benzalkonium thiamine, the replication of SARS-CoV-2 is inhibited, and the infected cells will not produce coronavirus. Research by the School of Biological Sciences at the University of Kent and the Institute of Medical Virology at Goethe University in Frankfurt found that the drug also increases the antiviral activity of “2-deoxy-D-glucose”; a drug that alters host cell metabolism to reduce virus reproduction.

This indicates that pentose phosphate pathway inhibitors such as benzalkonium thiamine are potential new treatment options for Covid-19, whether used alone or in combination with other treatments. In addition, the antiviral mechanism of Benfooxythiamin is different from other Covid-19 drugs such as remdesivir and molnupiravir. Therefore, these resistant viruses may be sensitive to phenoxythiamine.

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Professor Martin Michaelis of the University of Kent said: “This is a breakthrough in Covid-19 treatment research. Since the development of drug resistance is a big problem in the treatment of viral diseases, the use of different target therapies is very important and provides further hope for Covid-19 develops the most effective treatment.” “Targeting virus-induced host cell metabolic changes is an attractive way to specifically interfere with the virus replication process,” added Professor Jindrich Cinatl from Goethe University Frankfurt.

News Source : Hindustan Times

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Laid stars Stephanie Hsu and Zosia Mamet reveal the worst gifts their romantic partners gave them | Exclusive

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Laid stars Stephanie Hsu and Zosia Mamet reveal the worst gifts their romantic partners gave them | Exclusive

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Stephanie Hsu and Zosia Mamet talk about their new series Laid, and some of the horrors of dating as millennials.
Imagine a scenario where anyone and everyone you have ever been intimate with begins to die one by one. Is it a curse? If yes, then who is cursed? These are questions that Stephanie Hsu‘s Ruby battles with in the new zany comedy, Laid. Ahead of the show’s release, Stephanie and co-star Zosia Mamet spoke exclusively with HT about their roles, the show’s unique premise, and the horrors of dating as millennials. (Also read: Dune: Prophecy star Emily Watson on working with Tabu: ‘She is a true treasure’)

Stephanie Hsu on her character’s flawed morality

Laid, created by Nahnatchka Khan and Sally Bradford McKenna, is the story of Ruby (Stephanie Hsu), who discovers that all her sexual partners are dying one by one, and she must warn them. Helping her in this unique quest is her best friend AJ (Zosia). The fun thing about Laid is that the protagonists are not the usual likeable characters. “She is totally an anti-hero of our story. I really love that,” says Stephanie, referring to Ruby’s moral greyness. “I am not a perfect person and I love playing flawed characters. But it was difficult. The creators told me that she is a total narcissist. But narcissists don’t think they are one, so I had to figure out a way to love her. For me, playing Ruby was about getting into her psychology and finding the innocent part of her – which is that she just wants love,” the actor adds.

While sitcoms usually add the best friend as the voice of reason trope, Laid diverges from that, with AJ even zanier and more morally ambiguous than Ruby. Talking about playing such a colourful character, Zosia Mamet says, “When you play not-so-likable or zany characters, people don’t believe they are that way. I don’t think AJ wakes up every morning and thinks, ‘I am absolutely crazy’. It’s about trusting the writing and finding an organic way into these characters to make them seem grounded, real, and relatable.”

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Stephanie, Zosia reveal the worst gifts they received from partners

In Laid, Ruby gives the gift of death to the men she is with, even if that is inadvertent. Ask the women about the worst ‘gift’ a partner has ever given them, and the discussions veer into the unusual horrors of modern-day dating. “I got a vintage wooden duck decoy from someone. It was broken, and I thought, ‘What does this say about our relationship?’. They didn’t know me well enough to know if I’d want this but also that they gave me something old and ailing,” Zosia says with a laugh.

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